Imaging Life: Biological Systems from Atoms to Tissues

Hardcover | September 11, 2014

EditorGary C. Howard, William E. Brown, Manfred Auer

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This volume provides an overview of a variety of approaches to biological image analysis, which allow for the study of living organisms at all levels of complexity and organization. These organisms range from individual macromolecules to subcellular and cellular volumes, tissues and microbialcommunities. Such a "systems biology" understanding of life requires the combination of a variety of imaging techniques, and with it an in-depth understanding of their respective strengths and limitations, as well as their intersection with other techniques. Howard, Brown, and Auer show us that theintegration of these imaging techniques will allow us to overcome the reductionist approach to biology that dominated the twentieth century, which was aimed at examining the physical and chemical properties of life's constituents, one macromolecule at a time. However, while based on the laws ofphysics and chemistry, life is not simply a set of chemical reactions and physical forces; it features an exquisite spatiotemporal organization that allows an inconceivably large number of chemical processes to coexist, refined by billions of years of evolutionary experimentation. And yet, many fundamental questions remain largely unanswered; Imaging Life argues that we are just now beginning to address the spatiotemporal organizational component of living processes. "Imaging" is needed in order to reveal the spatiotemporal relationships between components, and thus tounderstand organizational guiding principles of living systems. Only through imaging will we be able to decipher the mechanisms and the marvelous organization that enable and sustain the mystery of life. Imaging Life shows us how biology is beginning to do just that.

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This volume provides an overview of a variety of approaches to biological image analysis, which allow for the study of living organisms at all levels of complexity and organization. These organisms range from individual macromolecules to subcellular and cellular volumes, tissues and microbialcommunities. Such a "systems biology" unders...

Throughout his career, Gary Howard has been a part of the academic, biotech, and publishing scientific communities. In addition, he has experience in multiple experimental systems, including mouse, human, and Drosophila. Since 2004. The late William E. Brown was professor of biological sciences at Carnegie Mellon University. From 1993...

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Format:HardcoverDimensions:432 pages, 9.25 × 6.12 × 0.98 inPublished:September 11, 2014Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195314433

ISBN - 13:9780195314434

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Table of Contents

1. Manfred Auer and Gary C. Howard: Imaging LifePart I: Imaging the Macromolecular Inventory Structure and Mechanistic Function of the Building BlocksManfred Auer, Natalia Pinzon, and Gary Howard: Introduction to Section 12. John P. Rose, M. Gary Newton and Bi-Cheng Wang: Protein crystallography and x-ray diffraction3. G. Marius Clore: Magnetic resonance in structural biology4. Phoebe Stewart: Cryo-electron microscopy5. K. Tanuj Sapra and Daniel J. Muller: Single-molecule imaging and force spectroscopy by atomic force microscopy6. Stefan Hau-Riege: Coherent x-ray diffraction imaging with free-electron lasersPart II: Imaging Cellular and Tissue Architecture: How It All Fits Together to Sustain LifeManfred Auer, Natalia Pinzon, and Gary Howard: Introduction to Section 27. Manfred Auer: Bridging the resolution gap: Electron tomography and advanced three-dimensional SEM approaches for cellular volumes8. Elizabeth A. Smith, Bertrand P. Cinquin, Gerry McDermott, Mark A. Le Gros and Carolyn A. Larabell: Correlated soft x-ray tomography and cryo-light microscopy9. Sethuramasundaram Pitchiaya, John R. Androsavich and Nils G. Walter: Breaking Abbe's law: Super-accuracy and super-resolution fluorescence microscopy based on single molecule detection10. Valentin Negerl: Superresolution STED microscopy11. Brendan Prideaux: Imaging the (macro)molecular composition: Mass spectrometry imaging12. Hoi-Ying Holman and Liang Chen: Non-destructive molecular mapping and imaging: Synchotron FTIR spectral imaging13. Martin Schmidt, Pradeep N. Perera, Alexander Weber-Bargioni, Paul D. Adams, and P. James Schuck: Raman spectroscopic imaging of biological systems14. Steven Finkbeiner: Automated microscopic imaging and survival statisticsPart III: Modeling of Complex Biological FunctionsManfred Auer, Natalia Pinzon, and Gary Howard: Introduction to Section 315. Chandrajit Bajaj: From voxel maps to models16. Hanchuan Peng: Building and using 3D digital atlases of complex model animals at single-cell resolutionConclusions17. Manfred Auer and Gary C. Howard: Quo vadis, imaging