Immobilized Biomolecules in Analysis: A Practical Approach

Paperback | October 1, 1998

EditorTony Cass, Frances S. Ligler

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Biomolecules and cells are critical components of biosensors and biomaterials, but in order to function in an artificial environment, they must be immobilized in a manner that does not affect their interaction with target analytes. Biosensors demonstrate that we can harness the incrediblefunctions of living molecules and cells for our own purposes and are therefore at the forefront of technology. Moreover the applications of immobilized biomolecules and cells are expected to expand far beyond biosensor applications and indeed are already used for pharmaceutical production andtesting. Biomaterials will become increasing common as they are being developed into toxic filters, artificial organs, and even silicon chips. This book provides a selection of methods for the immobilization of biomolecules and cells on a variety of surface with different geometries and chemistriesso that they retain their function and guidelines on which method to use. Also included are the analytical techniques to measure the functionality of immobilized biomolecules. All the protocols have been tried and validated by the authors. Immobilized Biomolecules in Analysis: A Practical Approachis an invaluable guide to all researchers in the fields of biosensors and biomaterials. Research in biosensors is carried out in a wide variety of fields including biochemistry, chemistry, engineering, laboratory medicine, environmental and defence research. The protocols are written so that anextensive prior knowledge of biochemistry is not required to use them.

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From the Publisher

Biomolecules and cells are critical components of biosensors and biomaterials, but in order to function in an artificial environment, they must be immobilized in a manner that does not affect their interaction with target analytes. Biosensors demonstrate that we can harness the incrediblefunctions of living molecules and cells for our ...

`r Cass is Reader in Bioanalytical Chemistry at Imperial College, London Dr Ligler is head of the Biosensors and Biomaterials Laboratory at the Naval Research Laboratory, USA
Format:PaperbackPublished:October 1, 1998Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199636362

ISBN - 13:9780199636365

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Table of Contents

Preface1. Silane-modified surfaces for biomaterial immobilization2. Avidin-biotin immobilization systems3. Antibodies as immobilization reagents4. Bioanalytical applications of self-assembled monolayers5. Protein adsorption: friend or foe?6. Micropatterning cell adhesiveness7. Sol-gel matrices for protein entrapment8. Immobilization of `smart' polymer-protein conjugates9. Kinetic analysis of the interaction between an analyte in solution and an immobilized protein10. Spectroscopic characterization of immobilized proteins11. Immobilization using electrogenerated polymersAppendixIndex

Editorial Reviews

"This book is invaluable to researchers in the fields of biosensors and biomaterials"Bioseparation Vol.9