Immunological Tolerance And Accommodation by Jeffrey PlattImmunological Tolerance And Accommodation by Jeffrey Platt

Immunological Tolerance And Accommodation

byJeffrey Platt

Hardcover | October 1, 2017

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Immunological Tolerance and Accommodationprovides the latest understanding of the cellular, molecular, and systematic regulation of immunological tolerance, an area that is of fundamental importance in immunology. For one hundred years, immunologists have struggled to understand how the immune system can attack with vigor and destroy foreign cells, microorganisms, and substances, all while sparing the immune individual from inadvertent injury.

Research in various fields of immunology has revealed molecular, cellular, and systemic means by which tolerance and accommodation develop, but no line of research, review article, or published volume has coordinated the various findings and theories that have emerged. This book provides the only comprehensive and unified consideration on immunological tolerance and accommodation.



  • Provides the only presentation that integrates molecular, cellular, and systemic mechanisms
  • Effectively coordinates both basic and clinical subjects
  • Addresses both tolerance and accommodation, providing the best available resource for understanding how autoimmunity and autoimmune diseases are averted in most individuals
  • Comprehensive and unified consideration of both tolerance and accommodation
Jeffrey L. Platt, M.D. directs the Transplantaion Biology Program at the University of Michigan where he serves also as Professor of Surgery and Professor of Microbiology and Immunology. Dr. Platt's research probes fundamental questions in transplantation biology and molecular medicine. The questions inlcude how immunity and inflammati...
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Title:Immunological Tolerance And AccommodationFormat:HardcoverDimensions:9.41 × 7.24 × 0.98 inPublished:October 1, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0124071953

ISBN - 13:9780124071957

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Table of Contents

1. Horror autotoxicus - A. the role of tolerance and accommodation in immunity. B. Definitions. C. Implications for health and diseases 2. Immunologic recognition and tolerance (structural tolerance) 3. Molecular mechanisms of tolerance (conditional tolerance) 4. Systemic tolerance 5. Molecular and cellular mechanisms of accommodation 6. When tolerance fails - autoimmunity and autoimmune diseases that ensue in relation to failure of specific mechanisms 7. Too much tolerance and accommodation - how tolerance and accommodation explain progression of cancer and persistence of infection