Immunopotentiators In Modern Vaccines

Hardcover | December 13, 2016

byVirgil SchijnsEditorDerek O'hagan

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Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful. Provides contributions from leading international authorities in the field Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines

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Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide su...

Dr. Virgil E.J.C. Schijns is special guest Professor in Cell Biology & Immunology group, Wageningen University, 6708 WD Wageningen, The Netherlands. Dr. Schijns received his Ph.D. degree at Utrecht University in 1990. Recent professional appointments are Chief Scientific Officer at ERC in Belgium and The Netherlands, (2011 to present);...

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Format:HardcoverDimensions:508 pages, 9.41 × 7.24 × 0.98 inPublished:December 13, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:012804019X

ISBN - 13:9780128040195

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Table of Contents

Unraveling the immunologist's dirty little secret
Modulation of innate immunity by particulate adjuvants
Dendritic cells as targets and adjuvants in (cancer) vaccines
Host-derived molecules as adjuvants
Discovery of immune potentiators as vaccine adjuvants
TLR 4 Reed (IDRI)
TLR 5
TLR 7/8
TLR 9 Davis (Pfiser)
Inulin adjuvants
Natural adjuvants (e.g. From Propolis)
Microparticles as vaccine delivery systems
MF59
AS01 adjuvant
Development and evaluation of AS04, containing MPL and aluminum salt
The ISCOMATRIXTM adjuvant
(CAF)
Mineral adjuvants
Mucosal vaccines and adjuvants
Skin adjuvants
Vaccination to treat non-infectious diseases: Surveying the opportunities
Regulatory aspects of vaccine adjuvants
Conclusion