Immunotherapy of Cancer by Mary L. DisisImmunotherapy of Cancer by Mary L. Disis

Immunotherapy of Cancer

EditorMary L. Disis

Paperback | December 9, 2010

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Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
Title:Immunotherapy of CancerFormat:PaperbackDimensions:528 pagesPublished:December 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617376450

ISBN - 13:9781617376450

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Table of Contents

Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic ApproachesÖzlem Türeci, Thorsten Klamp, Michael Koslowski, Sebastian Kreiter, and Ugur SahinCurrent Strategies for the Identification of Immunogenic Epitopes of Tumor AntigensLudmila Müller, Stephanie McArdle, Evelyna Derhovanessian, Thomas Flad, Ashley Knights, Robert Rees, and Graham PawelecCurrent and Future Role of Natural-Killer Cells in Cancer ImmunotherapyLisa M. Harlan and Julie Y. DjeuThe Role of Immune Monitoring in Evaluating Cancer ImmunotherapyHolden T. MaeckerStatistical Analysis of Immune Response Assays in Cancer Immunotherapy TrialsSusan GroshenDNA Vaccines for Cancer ImmunotherapyHeesun Kwak and Howard L. KaufmanDendritic CellsWeiping Zou and Tyler J. CurielDifferent Approaches to Dendritic Cell-Based Cancer ImmunotherapyNoweeda Mirza and Dmitry GabrilovichAnti-Idiotype Antibody Vaccines for the Immunotherapy of CancerMalaya Bhattacharya-Chatterjee, Nitin Rohatgi, Sunil K. Chatterjee, Asim Saha, Rakesh Shukla, and Kenneth A. FoonAutologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer TherapeuticsJie Dai and Zihai LiTumor-Reactive T-Cells for Adoptive ImmunotherapyHelga Bernhard, Julia Neudorfer, Kerstin Gebhard, Heinke Conrad, Dirk H. Busch, and Christian PeschelT-Cell Adoptive Immunotherapy of Cancer: From Translational Models to Clinical SignificancePeter A. Cohen, Mohamed Awad, and Suyu ShuRetroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-CellsJeffrey J. Roszkowski and Michael I. NishimuraHarnessing the Potential of Graft-vs-TumorNancy M. Hardy and Michael R. BishopTumor-Induced Immune Suppression and Immune Escape: Mechanisms and Impact on the Outcome of Immunotherapy of Malignant DiseaseMichael Campoli and Soldano FerroneThe Tumor Microenvironment: Regulation of Antitumor Immunity and Implications for ImmunotherapyGeorge Coukos and Jose-Ramon Conejo-GarciaManipulation of Lymphocyte Homeostasis for Enhancing Antitumor ImmunityEduardo Davila and Esteban CelisFast-Lane Evolution in the Tumor MicroenvironmentGabriella Marincola and Francesco M. MarincolaManipulating Immunological Checkpoints to Maximize Antitumor ImmunityLeisha A. Emens, R. Todd Reilly, and Elizabeth M. JaffeeInterleukin-2 as Cancer TherapyJoseph I. Clark and Kim A. MargolinBiological and Clinical Properties of the Type 1 InterferonsDouglas W. Leaman, Shaun Rosebeck, and Ernest C. BordenPromising g-Chain Cytokines for Cancer Immunotherapy: Interleukins-7, -15, and -21 as Vaccine Adjuvants, Growth Factors and ImmunorestorativesTerry J. Fry and Crystal L. MackallThe Therapeutic Use of Natural-Killer Cells in Hematological MalignanciesSherif S. Farag and Michael A. CaligiuriAntibody Therapy for Solid TumorsCristina I. Truica, Dorinda Rouch, and Carlos L. ArteagaAntibody Therapy for Non-Hodgkin's LymphomaStephen M. Ansell and Thomas E. WitzigApproaches to In Vivo Imaging of Cancer ImmunotherapyGeorge A. Vielhauer, Bond Almand, Mary L. Disis, David A. Mankoff, and Keith L. KnutsonDesign Issues for Early-Stage Clinical Trials for Cancer VaccinesGina R. PetroniMonoclonal Antibody Therapy of CancerHossein Borghaei, Matthew K. Robinson, and Louis M. WeinerIndex

Editorial Reviews

From the reviews:"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. . The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers . ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)