Improved Non-steroid Anti-inflammatory Drugs: Cox-2 Enzyme Inhibitors by Sir John R. VaneImproved Non-steroid Anti-inflammatory Drugs: Cox-2 Enzyme Inhibitors by Sir John R. Vane

Improved Non-steroid Anti-inflammatory Drugs: Cox-2 Enzyme Inhibitors

bySir John R. VaneEditorJack H. Botting, R.M. Botting

Paperback | December 25, 2011

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This volume contains the proceedings of the William Harvey Conference held in London, 10-11 October, 1995. It covers the molecular biology and physiological functions of the cyclo-oxygenase enzymes, as well as the experimental and clinical aspects of the recently discovered inhibitors of the inducible cyclooxygenase. Particular attention has been directed at the discussion of the selectivity of non-steroid anti-inflammatory drugs for cyclooxygenase-2 and their propensity to cause gastric and kidney damage. Sir John Vane is the Director General, Regina Botting the Information Scientist, and Jack Botting Consultant at the William Harvey Research Institute, an independent charitable foundation carrying out research into cardiovascular disease inflammation and metabolic disorders within Queen Mary and Westfield College of the University of London, UK. Sir John Vane was awarded the Nobel Prize in 1982 for his discoveries of the mechanism of action of aspirin and of the physiological role of prostacyclin and other prostanoids.
Sir John Vane is the Director General at the William Harvey Research Institute, an independent charitable foundation within Queen Mary and Westfield College of the University of London, UK. Sir John Vane shared the Nobel Prize in Physiology or Medicine in 1982 for his discoveries of the mechanism of action of aspirin and of prostacyc...
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Title:Improved Non-steroid Anti-inflammatory Drugs: Cox-2 Enzyme InhibitorsFormat:PaperbackDimensions:200 pages, 23.5 × 15.5 × 0.01 inPublished:December 25, 2011Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9401090319

ISBN - 13:9789401090315

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Table of Contents

Preface. 1. Overview - Mechanisms of Action of Anti-Inflammatory Drugs; J. Vane, R. Botting. 2. The Three-Dimensional Structure of Cyclooxygenases; R.M. Garavito. 3. The Dilemma of Two Cyclooxygenases: Identifying the Roles of COX-1 and COX-2 in Inflammation and Apoptosis; D. Simmons, et al. 4. Inducible Enzymes with Special Reference to COX-2 in the Inflammatory Response; D. Willoughby, et al. 5. NSAID Mechanism of Action: The Role of Intracellular Pharmacokinetics; L. Herbette, et al. 6. Differential Inhibition of COX-1 and COX-2 in vitro and Pharmacological Profile in vivo of NSAIDs; M. Pairet, G. Engelhardt. 7. COX-2 Expression and Inhibition in Human Monocytes; C. Patrono, et al. 8. Expression and Regulation of COX-2 in Synovial Tissues of Arthritic Patients; L. Crofford. 9. An Inhibitor of Injury-Induced COX-2 Transcriptional Activation Elicits Neuroprotection in a Brain Damage Model; N. Bazan, G. Allan. 10. COX-2 Expression in Labour; P. Bennett, D. Slater. 11. Re-Evaluation of Gut Toxicity of NSAIDs; D.N. Bateman. 12. NSAID: Can Renal Side Effects be Avoided? J. Frölich, D. Stichtenoth. 13. Pharmacology, Safety Data and Therapeutics of COX-2 Inhibitors; P. Emery. Index.