In Search of Madness: Schizophrenia and Neuroscience by R. Walter HeinrichsIn Search of Madness: Schizophrenia and Neuroscience by R. Walter Heinrichs

In Search of Madness: Schizophrenia and Neuroscience

byR. Walter Heinrichs

Hardcover | March 15, 2001

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Over the last two decades, scientific articles on schizophrenia have doubled in number, and prophecies of breakthrough have appeared and receded. The result is a scattered and confusing mass of evidence that is difficult to evaluate. How much progress has really been made? Are the neurologicalcauses of madness truly in sight? This book evaluates the progress of schizophrenia science by summarizing what is known about how patients with the illness differ from healthy people. The tools of meta-analysis are first explained and then employed to make the strength and consistency of these differences explicit. Beginning withthe study of symptoms, then moving through the search for objective disease markers, findings on the cognitive functions, structure, physiology, chemistry, and development of the brain, this book is a journey into the enigma of madness and its science. What emerges is an illness that reveals itselfmost strongly in thought processes, not biology. As evidence actually becomes weaker and harder to reproduce as research moves from mind to molecule, the harvest of dazzling research techniques turns out to be modest or inconsistent. Schizophrenia is an anomaly at the frontier of mind and brain, but In Search of Madness points the way to itssolution.
R. Walter Heinrichs is at York University.
Title:In Search of Madness: Schizophrenia and NeuroscienceFormat:HardcoverDimensions:368 pages, 5.91 × 9.02 × 1.18 inPublished:March 15, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195122194

ISBN - 13:9780195122190

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Table of Contents

1. Illness and EvidenceThe Science of SchizophreniaRules of EvidenceConclusion2. The Nature of SymptomsPsychiatric PioneersSymptoms and DiagnosisThe Mind of MadnessThe Delusional WorldCounterfeit ExperienceCrazy ThoughtsGeneral Summary and Conclusions3. The Mark of MadnessCandidate Markers of SchizophreniaTraits and StatesSpecificityMarking GenesConclusions4. Executive IncompetenceThe Search for the Schizophrenic LesionThe Frontal Brain and Its MindSchizophrenia and the Frontal MindPictures of the BrainThe Frontal-Executive Brain and its Contribution to Schizophrenia5. The Biology of MeaningThe Temporal Lobe and its Semantic FunctionsSchizophrenia and the Semantic BrainNeurobiology of the Temporal Lobe in SchizophreniaThe Temporal-Semantic Brain and its Contribution to Schizophrenia6. Neurochemical TempestDopamine: Modulator of Mind and MovementSerotonin: Chemical of Sleep and MoodsGlutamate: The Brain's WorkhorseGeneral Summary and Conclusions7. The Strangeness of ChildrenEssentials of Genetics and Early NeurodevelopmentNeurodevelopmental Evidence and SchizophreniaAbnormalities of Children Vulnerable to SchizophreniaSummary and Conclusions8. Flights of TheoryRoot Problems for Theories of SchizophreniaSchizotaxia, Schizotypy and SchizophreniaNeurodevelopmental Diathesis-Stress TheoriesSummary and Synthesis9. The End of the BeginningThe Neuroscience SweepstakesThe Promissory NoteMultiple Disease StatesThe Anomaly at the Frontier of Mind and BrainConclusion

Editorial Reviews

"I admire someone like R. Walter Heinrichs who is not afraid to wrestle with a moving mountainHeinrichs has attempted to evaluate all studies on schizophrenia published since 1980 and to weigh the quality of evidence on various theories of this disease. To his credit, he does so by usingrules of evidence, meta-analyses, calculations of the effect size, and than 1,000 references. In Search of Madness: Schizophrenia and Neuroscience is well organized and well writtenThe authors provide a practical review of acute psychopharmacology and behavioral intervention techniques to assist theclinician in this endeavor."--Psychiatric Services, E. Fuller Torrey