In Situ Hybridization in Neurobiology: Advances in Methodology

Hardcover | April 1, 1993

EditorJames H. Eberwine, Karen L. Valentino, Jack D. Barchas

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In situ hybridization has become an important and widely used research tool for neurobiologists since the authors' first book on the subject, In Situ Hybridization: Applications to Neurobiology (Oxford, 1987). This new volume examines the methodological advances that have been made in in situhybridization techniques and their impact on the study of the nervous system. These include methods for improving sensitivity, ways of examining multiple mRNAs within the same section, ways of examining both proteins and mRNAs within the same section, and methods for using in situ hybridizationtechnology to examine areas of cellular biological significance, such as translational control. The development of alternative labels to radioactivity for the detection of hybridized probes, and the combined use of in situ hybridization and immunocytochemistry is also covered in this book. Itdiscusses the quantification of in situ hybridization signal and presents an overview of information generated by using in situ hybridization in diagnostic medicine. This volume will be essential to researchers in the neurosciences as well as those in other disciplines.

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In situ hybridization has become an important and widely used research tool for neurobiologists since the authors' first book on the subject, In Situ Hybridization: Applications to Neurobiology (Oxford, 1987). This new volume examines the methodological advances that have been made in in situhybridization techniques and their impact on...

James H. Eberwine is at University of Pennsylvania. Karen L. Valentino is at Neurex Corporation, Menlo Park, California.

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Format:HardcoverDimensions:222 pages, 9.49 × 6.26 × 0.71 inPublished:April 1, 1993Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195075072

ISBN - 13:9780195075076

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Table of Contents

1. J. Eberwine: Methodological Considerations in the Utilization of In Situ Hybridization2. C.D. Toran-Allerand and R.C. Miranda: Combining Non-Isotopic In Situ Hybridization Histochemistry with Steroid Autoradiography3. P.C. Emson, B. Heppelman, and S.M. Augood: Development of Techniques to Combine Isotpic and Non-Isotopic In Situ Hybridization and Immunocytochemistry for Phenotypic Characterization of Individual Neurons4. F. Baldino, Jr., E. Robbins, and M.E. Lewis: Enzyme Histochemical Detection of Neuronal mRNA5. S.L. Petersen and S. McCrone: Characterization of the Receptor Complement of Individual Neurons Using Dual-Label In Situ Hybridization Histochemistry6. P.M. Wise, et al.: Assessment of Peptide Secretion and Gene Expression within Individual Cells7. O. Yeralan, et al.: Quantitative Micro-IIn Situ Hybridization8. M.F. Chesselet and L.T. Weiss-Wunder: Quantification of In Situ Hybridization Histochemistry9. J.L. Roberts and N. Levin: Analysis of Transcription Levels Using Intervening Sequence In Situ Hybridization10. R.E. Tanzi and B.T. Hyman: Analysis of Alternatively-Transcribed Messages in Brain by In SItu Hybridization Using Biotinylated Oligonucleotide Probes11. O. Bagasra, T. Seshamma, and R.J. Pomerantz: In Situ Polymerase Chain Reaction: A Powerful New Methodology12. K. Miyashiro, et al.: In Situ Transcription: Methodology and Multi-Faceted Applications