In Vitro Methods in Pharmaceutical Research

Other | October 4, 1996

byJose V. Castell, Jose V. Castell, Maria Jose Gmez-Lechn

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In VitroMethods in Pharmaceutical Researchprovides a comprehensive guide to laboratory techniques for evaluatingin vitroorgan toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellularin vitromodels for toxicology and pharmacology studies.

Key Features
* Meets the continuing demand for information in this field
* ComparesIn Vitrotechniques with other methods
* Describes cell-culture methods used to investigate toxicity in cells derived from different organs
* Includes contributions by leading experts in the field

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From the Publisher

In VitroMethods in Pharmaceutical Researchprovides a comprehensive guide to laboratory techniques for evaluatingin vitroorgan toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques availa...

Format:OtherDimensions:467 pages, 1 × 1 × 1 inPublished:October 4, 1996Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080534600

ISBN - 13:9780080534602

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Table of Contents

D.W. Straughan, J.H. Fentem, and M. Balls, Replacement Alternative and ComplementaryIn VitroMethods in Pharamaceutical Research.
M.D. Barratt and M. Chamberlain, Integration of QSAR andIn VitroToxicology.
F.A. Barile, Continuous Cell Lines as a Model for Drug Toxicity Assessment.
P. Bach,In VitroModels for Nephrotoxicity Studies.
A.E.M. Vickers, ExperimentalIn VitroModels to Evaluate Hepatotoxicity.
M.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell, Isolation, Culture and Use of Human Hepatocytes in Drug Research.
E. McFarlane-Abdulla, and I.C. Campbell, Studies of Nephrotoxicity in Cellular Studies.
M. Adolphe, S. Thenet-Gauci, and S. Demignot, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs.
E. Chacon, D. Acosta, and J.J. Lemasters, Primary Cultures of Cardiac Myocytes asIn VitroModels for Pharmacological andToxicological Assessments.
R. Roguet, Cutaneous PharmacotoxicologyIn Vitro.
H. Spielmann, Ocular Irritation.
M.A. Miranda, Phototoxicity of Drugs.
I. de G. Mitchell and R.D. Combes,In VitroGenotoxicity and Cell Transformation Assessment.
B. Schmid, R. Bechter, and P. Kucera, The Use of Whole Embryo Cultures inIn VitroTeratogenicity Testing.
J.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort,In VitroInvestigation of the Molecular Mechanisms of Hepatotoxicity.
A. Guillouzo, Biotransformation of Drugs by Hepatocytes.
K. Mace, E.A. Offord, and A.M.A. Pfeifer, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells.