In vivo NMR Imaging: Methods and Protocols by Leif SchröderIn vivo NMR Imaging: Methods and Protocols by Leif Schröder

In vivo NMR Imaging: Methods and Protocols

EditorLeif Schröder, Cornelius Faber

Hardcover | August 31, 2011

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Nuclear magnetic resonance imaging represents a technique that is indispensable in every day biomedical diagnostics. Thanks to the numerous ways to manipulate and detect an NMR signal, it is possible to obtain a variety of information with excellent spatial and temporal resolution. Today's MRI techniques go far beyond the illustration of pure anatomical structures and include the revealing of processes down to the molecular level. The number of small animal imaging centers relying on MRI as a key method for preclinical research to understand diseases and to test for novel treatments is growing rapidly. In Vivo NMR Imaging: Methods and Protocols is written as an experimental laboratory text to provide a descriptive approach of the various applications of magnetic resonance imaging and its underlying principles. Starting from a compact introduction of basic NMR physics and image encoding techniques suitable for a broad audience in the life sciences, the concept focuses on addressing the many ways of generating contrast in MR images. The authors cover an interdisciplinary range of problems to be addressed by this non-invasive modality, including study protocols for addressing morphological, physiological, functional, and biochemical aspects of various tissues in living organisms. Information about practical aspects of designing experimental studies that follow the special conditions for micro imaging setups are also provided.  Written in the successful Methods in Molecular BiologyT series format, In Vivo NMR Imaging: Methods and Protocols aims to be an experimental compendium of modern in vivo MR imaging with special focus on recent developments in molecular imaging and new protocols for imaging metabolism and molecular markers.
Title:In vivo NMR Imaging: Methods and ProtocolsFormat:HardcoverDimensions:766 pagesPublished:August 31, 2011Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617792187

ISBN - 13:9781617792182

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Table of Contents

Part I. Basics of MRI               1. Physical Basics of NMR                                                                                         Rolf Pohmann  2. Spatial Encoding - Basic Imaging Sequences                                                         Rolf Pohmann  3. Basic Contrast Mechanisms                                                                                    Leif Schröder and Cornelius Faber                  4. Scanner Components                                                                                              Volker Behr 5. Small Animal Preparation and Handling in MRI                                       Patrick McConville Part II. Special Techniques                  6. Cerebral Perfusion MRI in Mice                             Frank Kober, Guillaume Duhamel, and Virginie Callot 7. High Field Diffusion Tensor Imaging in Small Animals and Excised Tissue            Bernadette Erokwu, Chris Flask, and Vikas Gulani 8. The BOLD Effect                                                                                                   Joan M. Greve 9. Screening of CEST MR Contrast Agents                           Xiaolei Song, Kannie W.Y. Chan, and Michael T. McMahon 10. Hyperpolarized Noble Gases as Contrast Agents                         Xin Zhou 11. Hyperpolarized Molecules in Solution                                                                  Jan Henrik Ardenkjaer-Larsen, Haukur Jóhannesson, Stefan J. Petersson, and Jan Wolber   12. MR Oximetry                                Jeff F. Dunn 13. MRI using Intermolecular Multiple-Quantum Coherences                      Rosa T. Branca                        Part III. Brain Applications 14. Experimental Stroke Research: The Contributions of In vivo MRI               Therése Kallur and Mathias Hoehn 15. Volumetry and Other Quantitative Measurements to Assess the Rodent Brain             Alize Scheenstra, Jouke Dijkstra, and Louise van der Weerd 16. Models of Neurodegenerative Disease - Alzheimer's Anatomical and Amyloid Plaque Imaging                       Alexandra Petiet, Benoit Delatour, and Marc Dhenain 17. MRI in Animal Models of Psychiatric Disorders             Dana S. Poole, Melly S. Oitzl, and Louise van der Weerd 18. Spectroscopic Imaging of the Mouse Brain                      Dennis W. J. Klomp and W. Klaas Jan Renema Part IV. Spine Applications                        19. Spinal Cord - MR of Rodent Models                  Virginie Callot, Guillaume Duhamel, and Frank Kober Part V. Cardiovascular Applications 20. Assessment of Cardiac Function             Jürgen E. Schneider  21. Plaque Imaging in Murine Models of Cardiovascular Disease                 Gert Klug, Volker Herold, and Karl-Heinz Hiller 22. Interventional MRI in the Cardiovascular System                       Harald H. Quick 23. MR for the Investigation of Murine Vasculature             Christoph Jacoby and Ulrich Flögel Part VI. Lung Applications                 24. MRI of the Lung: Non-invasive Protocols and Applications to Small Animal Models of Lung Disease            Magdalena Zurek and Yannick Crémillieux Part VII. Cancer Models                     25. Characterization of Tumor Vasculature in Mouse Brain by USPIO Contrast-enhanced MRI                Giulio Gambarota and William Leenders 26. Cancer Models - A Multiparametric Application of MRI in Rodent Hepatic Tumor Model                   Feng Chen, Frederik De Keyzer, and Yicheng Ni Part VIII. Functional MRI                  27. BOLD MRI Applied to a Murine Model of Peripheral Artery Disease               Joan M. Greve 28. Manganese-enhanced Magnetic Resonance Imaging            Susann Boretius and Jens Frahm 29. Spin Echo BOLD fMRI on Songbirds                 Colline Poirier and Anne-Marie Van der Linden Part IX. Phenotyping               30. MRI to Study Embryonic Development              Bianca Hogers 31. Mouse Phenotyping with MRI                                                                                         X. Josette Chen and Brian J. Nieman 32. Analysis of Freshly Fixed and Museum Invertebrate Specimens using High-resolution, High-throughput MRI                                    Alexander Ziegler and Susanne Mueller Part X. Metabolic and Targeted Imaging                    33. Applications of Hyperpolarized Agents in Solutions                                           Jan Henrik Ardenkjaer-Larsen, Haukur Jóhannesson, J. Stefan Petersson, and Jan Wolber 34. Target-specific Paramagnetic and Superparamagnetic Micelles for Molecular MR Imaging                               Roel Straathof, Gustav J. Strijkers, and Klaas Nicolay 35. Tracking Transplanted Cells by MRI - Methods and Protocols                           Michel Modo 36. MRI of CEST Based Reporter Gene                                Guanshu Liu and Assaf A. Gilad