Individualized Drug Therapy For Patients: Basic Foundations, Relevant Software And Clinical Applications by Roger W JelliffeIndividualized Drug Therapy For Patients: Basic Foundations, Relevant Software And Clinical Applications by Roger W Jelliffe

Individualized Drug Therapy For Patients: Basic Foundations, Relevant Software And Clinical…

byRoger W JelliffeEditorMichael Neely

Paperback | November 11, 2016

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Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applicationsfocuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose.

The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.



  • Uses pharmacokinetic approaches as the tools with which therapy is individualized
  • Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based
  • Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches
  • Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal
Roger Jelliffe MD, FCP, FAAPS, an adult cardiologist, developed the first software, for individualizing digitalis dosage, in 1967. He founded the USC Laboratory of Applied Pharmacokinetics and directed it until he retired and had recruited Dr. Michael Neely, who became director in 2013. The laboratory has developed what is now the USC ...
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Title:Individualized Drug Therapy For Patients: Basic Foundations, Relevant Software And Clinical…Format:PaperbackDimensions:434 pages, 8.75 × 6.35 × 0.68 inPublished:November 11, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128033487

ISBN - 13:9780128033487

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Table of Contents

Section I: Basic Techniques for Individualized Therapy

Chapter 1. Basic Pharmacokinetics and Dynamics for Clinicians

Chapter 2. Describing Drug Behavior in Groups of Patients

Chapter 3. Developing Maximally Precise Dosage Regimens for Patients Multiple Model (MM) Dosage Design

Chapter 4. Optimizing Laboratory Assay Methods for Individualized Therapy

Chapter 5. Evaluation of Renal Function

Section II: The Clinical Software

Chapter 6. Using the BestDose Clinical Software Examples With Aminoglycosides

Chapter 7. Monitoring the Patient: Four Different Bayesian Methods to Make Individual Patient Drug Models

Chapter 8. Monitoring Each Patient Optimally: When to Obtain the Best Samples for Therapeutic Drug Monitoring

Chapter 9. Optimizing Individualized Drug Therapy in the ICU

Chapter 10. Quantitative Modeling of Diffusion Into Endocardial Vegetations, the Postantibiotic Effect, and Bacterial Growth and Kill

Chapter 11. Individualizing Digoxin Therapy

Section III: Clinical Applications of Individualized Therapy

Chapter 12. Optimizing Single-Drug Antibacterial and Antifungal Therapy

Chapter 13. Combination Chemotherapy With Anti-Infective Agents

Chapter 14. Controlling Antiretroviral Therapy in Children and Adolescents with HIV Infection

Chapter 15. Individualizing Tuberculosis Therapy

Chapter 16. Individualizing Transplant Therapy

Chapter 17. Individualizing Dosage Regimens of Antineoplastic Agents

Chapter 18. Controlling Busulfan Therapy in Children

Chapter 19. Individualizing Antiepileptic Therapy for Patients

Chapter 20. Individualizing Drug Therapy in the Elderly

Chapter 21. The Present and Future State of Individualized Therapy