Inflammation and Cancer: Methods and Protocols: Volume 2, Molecular Analysis and Pathways by Serguei V. KozlovInflammation and Cancer: Methods and Protocols: Volume 2, Molecular Analysis and Pathways by Serguei V. Kozlov

Inflammation and Cancer: Methods and Protocols: Volume 2, Molecular Analysis and Pathways

EditorSerguei V. Kozlov

Paperback | November 19, 2010

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According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular BiologyT series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.

Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.

Title:Inflammation and Cancer: Methods and Protocols: Volume 2, Molecular Analysis and PathwaysFormat:PaperbackDimensions:424 pagesPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617379050

ISBN - 13:9781617379055

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Table of Contents

Part I. Crossroads of Inflammation and Cancer: Molecular AspectsChapter 1. Immunohistochemical Analysis of 8-nitroguanine, a Nitrative DNA Lesion, in Relation to Inflammation-Associated CarcinogenesisYusuke Hiraku and Shosuke KawanishiChapter 2. Molecular Analysis of Genetic Instability Caused by Chronic InflammationBin Yan, Yuanlin Peng, and Chuan-Yuan LiChapter 3. Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF PathwaysNomeli P. Nunez, Stephen D. Hursting, Shoshana Yakar, Dan Fowler, and Charles VinsonChapter 4. Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-kBFui G. Goh, Helen Banks, and Irina A. UdalovaChapter 5. Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell TranscriptomeHiromu Suzuki, Minoru Toyota, Yutaka Kondo, and Yasuhisa ShinomuraChapter 6. cDNA Microarray Analysis of Inflammatory Breast Cancer SignaturesSteven J. Van Laere, Peter B. Vermeulen, and Luc Y. DirixChapter 7. Analysis of the TLR/NF-kB Pathway in Antigen-Presenting Cells in Malignancies Promoted by InflammationJ. Magarian BlanderChapter 8. Induced Nitric Oxide Synthase (iNOS) as a Major Player in the Oncogenic Transformation of Inflamed TissueGuang-Yu Yang, Sofia Taboada, and Jie Liao Part II. Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery in Inflammation-Related OncogenesisChapter 9. Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-Cancer Drug Candidates in a High-Throughput FormatSerguei V. KozlovChapter 10. The NF-kB Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-kB ActivityClaudio Mauro, Francesca Zazzeroni, Salvatore Papa, Concetta Bubici, and Guido FranzosoChapter 11. Inhibiting Pro-Inflammatory NF-kB Signaling Using Cell-Penetrating NEMO Binding Domain (NBD) PeptidesLisa A. Madge and Michael J. MayChapter 12. Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis PatientsScott Thomson and Irina A. UdalovaChapter 13. Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with TumorigenesisBozena KaminskaChapter 14. Molecular Characterization of STAT Signaling in Inflammation and TumorigenesisAlicja Adach, Aleksandra Ellert-Miklaszewska, and Bozena KaminskaChapter 15. Inflammation and Tumor Progression: A Lesson from TNF-a-Dependent FAK Signaling in CholangiocarcinomaNaing Naing Mon, Toshio Kokuryo, and Michinari HamaguchiChapter 16. Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPARd -> 14-3-3e Pathway Kenneth K. Wu and Jun-Yang LiouChapter 17. PPARb/d Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma CellsJeffrey D. Ritzenthaler, Jesse Roman, and ShouWei HanChapter 18. Investigating Macrophage and Malignant Cell Interactions In vitroThorsten Hagemann and Toby LawrenceChapter 19. Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anti-Cancer TherapyPierre SmirnovChapter 20. Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Canc

Editorial Reviews

From the reviews:"Chapters in this volume are designed to be guides to techniques addressing various aspects of experimental cancer biology. . this volume will earn a place on the lab benches of investigators and clinicians who are studying inflammation-related oncogenesis. . this book can provide a source of information for establishing new techniques as well as suggestions for investigating particular aspects of tumorigenesis." (Marion C. Cohen, Doody's Review Service, December, 2009)