Inflammation: Mechanisms and Treatment: Proceedings of the Fourth International Meeting on Future Trends in Inflammation Organized by the E by D.A. WilloughbyInflammation: Mechanisms and Treatment: Proceedings of the Fourth International Meeting on Future Trends in Inflammation Organized by the E by D.A. Willoughby

Inflammation: Mechanisms and Treatment: Proceedings of the Fourth International Meeting on Future…

EditorD.A. Willoughby, J.P. Giroud

Paperback | June 24, 2012

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This report on Future Trends in Inflammation IV records another of the multidisciplinary meetings organized by the European Biological Research Association. The organizers wish to record their thanks to all the participants and delegates who made this such an enjoyable meeting. Our thanks are due to a number of members of the pharmaceutical industry who so kindly donated funds. These funds were used to provide grants for young research workers to attend this meeting. Many people have kindly given their time and help to make this congress possible. It is impossible to list them by name, but we are profoundly grateful. We were dubious at the outset as to whether to hold this meeting in a period when many other meetings are being organized on inflammation. The enthusiastic attendance proves that we were right in going ahead. The next international meeting will be held in France in 1983. For further details please contact: Professor J. P. Giroud Department of Pharmacology, Hopital Cochin 75014 Paris, France D. A. Willoughby J. P. Giroud xxxiii Section I Future Trends CHAIRMAN: L. Chedid CO-CHAIRMAN: Dame Honor Fell 1 The participation of mononucleur phagocytes in immune based inflammatory processes with special reference to their secretory responses P. DAVIES AND R. J.
Title:Inflammation: Mechanisms and Treatment: Proceedings of the Fourth International Meeting on Future…Format:PaperbackPublished:June 24, 2012Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:940109425X

ISBN - 13:9789401094252

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Table of Contents

Section I: Future Trends.- 1 The participation of mononucleur phagocytes in immune based inflammatory processes with special reference to their secretory responses.- Discussion.- 2 Future trends in mechanisms of cartilage destruction (Abstract).- Discussion.- 3 New developments in leukocyte Chemotaxis research: a survey.- Discussion.- 4 Future trends in free radical studies.- Discussion.- 5 Future trends in the immunopathology of rheumatoid arthritis.- Discussion.- 6 Future trends in anti-rheumatic drugs.- Discussion.- Section II: Review of Current Developments.- 7 A review of mechanism of action of steroid and non-steroid anti-inflammatory drugs.- Discussion.- 8 Review of immunotherapy in rheumatoid arthritis.- Discussion.- 9 Crystal deposition disease.- Discussion.- 10 T-cell dependent inflammatory responses.- Discussion.- 11 Arachidonic acid peroxidation in inflammation and its inhibition as a mechanism for anti-inflammatory activity.- 12 General Discussion.- Section III: Anti-Inflammatory and Anti-Rheumatic Agents.- 13 Review of pathogenesis of adjuvant arthritis and its relation to rheumatoid arthritis (Abstract).- 14 The anti-inflammatory activity of aspirin: the active metabolite.- 15 Indomethacin-sodium salicylate combination/RGH-6705 as a new possibility in the treatment of inflammation (Abstract).- 16 Tropesin: a new potential anti-rheumatic ester of indometacin.- 17 Development of an Arthus-like model of induced inflammation and its use in the anti-inflammatory characterization of orgotein (bovine Cu-Zn superoxide dismutase).- 18 The inhibition of macrophage accumulation in rats following injection of complete Freund's adjuvant (Abstract).- 19 Possible synergism between ovariectomy and oestradiol in preventing Freund's adjuvant arthritis in the rat.- 20 Anti-inflammatory actions of an immunomodulator: therafectin 1,2-O-isopropylidene-3-O-3?-(N', N'-dimethlyamino n-propyl)-D-gluco-furanose, HCl.- 21 Effects of benoxaprofen on macrophage function (Abstract).- 22 Some 'anti-arthritic' properties of an oversulphated glycosaminoglycan in degenerative joint disease.- 23 Anti-arthritic properties of ICI 55897 ('Clozic') (Abstract).- 24 Effect of ICI 55897 ('Clozic'), indomethacin and dexamethasone on collagenase and prostaglandin production by cultured rheumatoid synovial tissue (Abstract).- 25 The use of thymopoietin as an anti-inflammatory agent (Abstract).- 26 Production of hydrogen peroxide from neutrophils of rats (Abstract).- 27 Effects of D-penicillamine on granulation tissue and connective tissue of skin, aorta and bone in rats (Abstract).- 28 D-penicillamine in rheumatoid arthritis: fixed versus variable regimes.- 29 Effects of anti-inflammatory drugs on polymorphonuclear leukocyte aggregation (Abstract).- 30 Aggregation of rat polymorphonuclear leukocytes in vitro by chemotactic factors (Abstract).- 31 Preliminary report on the effect of a new derivative of acetyl salicylic acid on tissue-algogen component due to damaging stimulation of cutis.- Discussion.- Section IV: Pharmacological Mediators.- 32 Changes in the inflammatory mediator content in the colonic mucosae of immune colitides in guinea pigs (Abstract).- 33 Simultaneous continuous monitoring of blood volume and permeability in rabbit synovium: action of histamine.- 34 Leukotriene B: a biologically active release product of polymorphonuclear leukocytes.- 35 Arachidonic acid metabolism by lipoxygenase in leukocytes of different species and the chemokinetic activity of some products (Abstract).- 36 Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenin pleural exudates (Abstract).- 37 The possible role of divalent cations, microtubules and cyclic nucleotides in lymphokine induced macrophage aggregation.- 38 Inhibitory effect of benoxaprofen and BW 755C on rabbit PMN leukocyte lipoxygenase (Abstract).- 39 Mechanism of inhibition of prostaglandin biosynthesis by anti-inflammatory steroids.- 40 Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity.- 41 Human haptoglobin: an endogenous inhibitor of prostaglandin synthase.- 42 Release of thromboxane B2 and PGE2 by rabbit polymorphonuclear leukocytes (Abstract).- 43 Prostaglandin and thromboxane production by rat macrophages (Abstract).- 44 Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis.- 45 Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis.- 46 Observations on the influence of anti-oxidant compounds on prostaglandin biosynthesis (Abstract).- 47 Preliminary data on the influence of thyroid function on prostaglandin biosynthesis (Abstract).- Discussion.- Section V: Experimental Models of Inflammation and Chemotaxis.- 48 Effect of pharmacologic agents on macrophage accumulation.- 49 The histology of cotton pellet and polyvinyl sponge induced granulomas in rats (Abstract).- 50 A biochemical and morphological study of the cotton pellet granuloma in the rat: effects of dexamethasone and indomethacin (Abstract).- 51 Neutrophil interactions with particulate materials: an in vitro model for inflammatory arthritides.- 52 An in vitro mouse macrophage model for use in assessing the effects of anti-inflammatory drugs.- 53 Monosodium urate monohydrate stimulates release of lysosomal enzymes and prostaglandins from macrophages.- 54 Comparison between calcium pyrophosphate and monosodic urate induced inflammations of the palatal connective tissue.- 55 Intracellular killing of micro-organisms by phagocytic cells: the effect of extracellular stimuli (Abstract).- 56 In vivo studies on the influence of antigen induced joint inflammation on patellar hyaline articular cartilage.- 57 A stereological analysis of collagen phagocytosis in a model of chronic inflammation in rats (Abstract).- 58 Modification of Chemotaxis and peptide binding during pathophysiological state of polymorphonuclear leukocytes.- 59 Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion (Abstract).- 60 Correlation between aggregative and Chemotaxis inducing activities of five chemotactic peptides (Abstract).- 61 On the mechanism of human polymorphonuclear leukocyte deactivation of Chemotaxis by the synthetic peptide formyl-methiony-leucyl-phenylalanine.- 62 Dynamics of membranes in viable leukocytes associated with cellular recognition and biological memory in Chemotaxis and promotion of locomotion in chemokinesis (Abstract).- Discussion.- Section VI: Measurement of Human and Experimental Inflammation.- 63 Quantitiative assessment of experimentally induced arthritis in guinea pigs using microfocal radiography.- 64 Glutathione in erythrocytes: a parameter of change in disease activity and response to drugs in rheumatoid arthritis.- 65 Effect of drugs on serum copper and its correlation with other humoral factors in rheumatoid arthritis.- 66 The effect of therapeutic agents on serum copper levels and serum oxidase activities in the rat adjuvant model compared to analogous results from studies of rheumatoid arthritis in humans.- 67 Serum and synovial fluid ferritin in rheumatoid arthritis.- 68 Circulating and intra-articular immune complexes in rheumatoid arthritis: their relationship with disease activity.- 69 ?2-microglobulin, anti-?2-microglobulin activity and circulating immune complexes in rheumatoid arthritis: seric and synovial studies.- 70 Technetium-99m labelled leukocytes: preparation, animal studies, and potential application.- 71 Knee rheumatoid synovitis (KRS) successfully treated with intra-articular rifamyicin SV (Abstract).- 72 HLADR typing and rheumatoid arthritis (RA) (Abstract).- 73 Preliminary studies comparing 67Ga uptake with 99mTc uptake and clinical score in rheumatoid arthritis (Abstract).- Discussion.- Section VII: Immune Aspects.- 74 Macrophage activation by Listeria-specific T cell sub-populations (Abstract).- 75 Activation of mouse peritoneal macrophages and of the alternative pathway of the complement system by cartilage specific collagen type II.- 76 Interaction of macrophages and synthetic polyanions in the inflammatory response.- 77 Activation of complement by metal compounds that induce chronic granulomatous inflammation.- 78 Different susceptibilities to 4-hydroperoxycyclophosphamide of T cell sub-sets involved in delayed-type hypersensitivity of mice to sheep red blood cells.- 79 RES impairment in NZB/W mice.- 80 Rheumatoid immunoblasts and the effect of gold and cytotoxic drugs.- 81 Immunological and clinical effects of human placenta-eluted gammaglobulins (PEGG) in rheumatoid arthritis.- 82 Modification of antibody responses during non-specific acute inflammation (Abstract).- 83 Levamisole and thymopoietin pentapeptide (TP5) correction of E-rosette depression in man. In vitro and in vivo studies.- 84 Comparison between a curative and a preventive effect of an immunological therapy on an experimental gingivitis.- 85 A prospective study of 17 autoantibodies (AA) in 176 cases of rheumatoid arthritis (RA) treated with D-penicillamine (DP) (Abstract).- 86 Lymphokines, monokines, leukokines: large scale production, isolation and properties of leukocyte-derived cytotaxins, cytokinesins, cytotoxins and mitogens (Abstract).- Discussion.- Section VIII: Inflammation - General Aspects.- 87 Experimental protoporphyria in hairless mice: Photodermatitis.- 88 Experimental protoporphyria in hairless mice: photohaemolysis versus Photodermatitis.- 89 Morphological studies of inflammatory reactions: the relationships between the delayed-type hypersensitivity reaction and the Arthus reaction induced in the rat with ovalbumin.- 90 Regulatory mediators in Arthus reactions: demonstration of chemotactic factor inactivator and cell directed inhibitor activity.- 91 Regulatory mediators in Arthus reactions: lysosomal enzymes in biopsy and serum.- 92 Effect of flurbiprofen on prostaglandin synthesis (Abstract).- 93 Intrapleural injection of asbestos induces early sister chromatid exchanges increase in bone marrow cells (Abstract).- 94 The effect of an acute inflammatory process on the resistance to infection in mice.- 95 Interaction of inflammatory stimuli: diminished inflammatory response induced by cell accumulation at a distant site (Abstract).- 96 Anti-inflammation in spontaneously arising animal cancers.- 97 Effect of tumour growth on inflammatory macrophages.- 98 Effect of an acute inflammatory process on tumour development.- 99 Role of endogenous pyrogen in the rabbit febrile responses to muramyl dipeptide (Abstract).- Discussion.- Section IX: Lymphocytes.- 100 Comparative migration of guinea pig T and B lymphocytes from capillary tubes (Abstract).- 101 T lymphocyte sub-populations in rheumatoid arthritis.- 102 Enkephalins and the immune system (Abstract).- 103 Experimental inhibition of E-rosette forming cells by in vitro incubation with adenosine, theophylline and verapamil.- 104 Lymphocytes bearing Fc ? receptors in rheumatoid arthritis: binding properties of the Fc receptors detected by Facb rosettes and 'high avidity' EA rosettes.- 105 'L' lymphocytes, immune complexes and the amplification of human T lymphocyte proliferation.- 106 Influence of anti-inflammatory drugs on PHA-stimulated lyn. phocyte proliferation with variable numbers of macrophages.- 107 Influence of regional blood flow and inflammation on the localization of lymphoblasts in the small intestine of the mouse.- 108 Early lymphocyte activation and proliferative response induced by lectins: individual variations in man.- 109 Lymphocyte responsiveness in acute and convalescent infectious mononucleosis (Abstract).- 110 Quantitative measurement of human leukocyte aggregation as a possible correlation with cell mediated immunity.- Discussion.- Section X: Enzymes and Cell Secretion Products.- 111 Macrophages as origin of factor increasing monocytopoiesis (FIM) (Abstract).- 112 Phagocytosis and enzymatic activity of PGE1 treated rat peritoneal macrophages (Abstract).- 113 Alterations in bone marrow leukocyte ultrastructure and alkaline phosphatase activity accompanying à peripheral inflammatory response in the rat (Abstract).- 114 In vivo inhibition of PMN migration by antimacrophage serum.- 115 Macrophage involvement in chemotactic response.- 116 Determination of free lipid A and endotoxin (Abstract).- 117 Mycoplasmas stimulate mouse peritoneal macrophages to secrete lysosomal enzymes and to be cytotoxic.- 118 Influence of colchine derivatives on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP after phagocytosis of monsodium urate crystals.- 119 Biological and biochemical activities of in vitro differentiating murine bone marrow macrophages (Abstract).- 120 Effect of synovial tissue on the matrix of articular cartilage in organ culture (Abstract).- 121 Effect of irradiation and cell reconstitution on the macrophage mitogenic activity of exudate and inflammatory serum.- 122 Effect of chronic inflammatory exudate on cell morphology and cell functions (Abstract).- 123 Macrophages are activated by endocytosis of ?2-macro-globulin-protease complexes to produce neutral proteases.- 124 A mitogenic factor for macrophages present in rat serum (Abstract).- 125 Secretion of plasminogen activator by mouse peritoneal macrophages elicited by injection of a suspension of killed Streptococci.- Discussion.