Integrins and Ion Channels: Molecular Complexes and Signaling by Andrea BecchettiIntegrins and Ion Channels: Molecular Complexes and Signaling by Andrea Becchetti

Integrins and Ion Channels: Molecular Complexes and Signaling

byAndrea BecchettiEditorAnnarosa Arcangeli

Hardcover | April 12, 2010

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Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases.

ANDREA BECCHETTI, PhD, is Professor of General, Comparative and Cellular Physiology at the Department of Biotechnology and Biosciences of the University of Milano-Bicocca, Italy. After receiving his academic degrees at the University of Milan, he has spent prolonged research sojourns at the Department of General Pathology of the Univer...
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Title:Integrins and Ion Channels: Molecular Complexes and SignalingFormat:HardcoverDimensions:124 pagesPublished:April 12, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441960651

ISBN - 13:9781441960658

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Table of Contents

1. Integrin Structure and Functional Relation with Ion ChannelsAnnarosa Arcangeli and Andrea BecchettiAbstractIntroductionFundamentals of Integrin StructurePhysiological and Pathological Implications: an Outline of Current TrendsConclusion2. Introduction to Ion ChannelsChiara Di Resta and Andrea BecchettiAbstractIntroductionThe Physiology of Ion ChannelsIon Channel Types Involved in Integrin?Mediated SignalingConclusion3. Biochemical Methods to Study the Interactions Between Integrins and Ion ChannelsOlivia CrocianiAbstractIntroductionYeast Two?Hybrid ScreeningAffinity?Based Screening: IP AssaysPull?Down AssayPhotoaffinity Labeling Techniques for Studying Transient Protein?ProteinInteractionFar Western Blot Analysis (Far WB)High?Throughput Protein?Protein Interaction Analysis, Followed by V alidation of Candidate Interactors through Different Experimental ApproachesPast and Future Application of Biochemical Approaches to Characterizethe Interactions between Integrins and Ion Channels4. Optical Methods in the Study of Protein?Protein InteractionsAlessio Masi, Riccardo Cicchi, Adolfo Carloni, Francesco Saverio Pavoneand Annarosa ArcangeliAbstractIntroductionFörster Resonance Energy Transfer: The "Molecular Ruler"Intensity Versus Lifetime: Two Ways to Measure FRETTotal Internal Reflection Fluorescence Microscopy (TIRFM) and Imagingof Membrane ProteinsAntibody?Based Versus Fusion Protein?Based FRET: PrinciplesAntibody?Based Versus Fusion Protein?Based FRET: Advantages and DisadvantagesApplication of Optical Methods to the Study of Integrins and Ion ChannelsConclusion5. Integrins and Signal TransductionSara Cabodi, Paola Di Stefano, Maria del Pilar Camacho Leal, Agata Tinnirello, Brigitte Bisaro, Virginia Morello, Laura Damiano, Simona Aramu,Daniele Repetto, Giusy Tornillo and Paola DefilippiAbstractOverview of Integrin StructureThe SFK?Fak?p130Cas SignalingConclusion6. Physical andFunctional Interaction between Integrins and hERG1 Channels in Cancer CellsSerena Pillozzi and Annarosa ArcangeliAbstractIntroductionhERG1 Channels in Cancer CellsEffects of Integrin Activation on hERG1 ChannelsIntegrins and hERG1 Channels form a Macromolecular ComplexEffects of hERG1 Activation on Integrin Function and SignalingConclusion7. Coordinated Regulation of Va scular Ca2+ and K+ Channels by Integrin SignalingPeichun Gui, Jun?Tzu Chao, Xin Wu, Yan Yang, George E. Davis and Michael J. DavisAbstractIntroductionRegulation of L?Type Calcium Channels by Integrin ActivationRegulation of Ca2+?Dependent Potassium Channels by Integrin ActivationConclusion: The Physiological Relevance of Coordinated Regulation of CaLand BK Channels by Integrins8. Adhesion?Dependent Modulation of Macrophage K+ ChannelsMargaret Colden?StanfieldAbstractIntroductionInwardly Rectifying K+ (Kir) CurrentsPhysiologic and Pathophysiologic Roles of Macrophage Kir ChannelsDelayed, Outwardly Rectifying K+ (Kdr) CurrentsPhysiologic and Pathophysiologic Roles of Macrophage Kdr ChannelsConclusion9. Integrin Receptors and Ligand?Gated ChannelsRaffaella Morini and Andrea BecchettiAbstractIntroductionThe Functional Significance of Integrins in the Adult BrainIntegrins and Nicotinic Acetylcholine Receptors: Not Only the Neuromuscular JunctionConclusion10. Integrins and Ion Channels in Cell Migration: Implications for Neuronal Development, Wound Healing and Metastatic SpreadAndrea Becchetti and Annarosa ArcangeliAbstractIntroductionThe Role of Integrins in Cell MigrationThe Role of Ion Channels and Crosstalk with Integrins in Cell MigrationCa2+ Signaling and the Axonal Growth ConeIon Channels as Adhesion MoleculesThe Cellular Environment and the Metastatic ProcessInvasiveness of Glial Tumors and Ion ChannelsConclusionIndex