Intramembrane-Cleaving Proteases (I-CLiPs) by Nigel M. HooperIntramembrane-Cleaving Proteases (I-CLiPs) by Nigel M. Hooper

Intramembrane-Cleaving Proteases (I-CLiPs)

byNigel M. HooperEditorUwe Lendeckel

Paperback | November 11, 2010

Pricing and Purchase Info

$234.95

Earn 1,175 plum® points

Prices and offers may vary in store

Quantity:

In stock online

Ships free on orders over $25

Not available in stores

about

In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called 'intramembrane-cleaving proteases' (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer's and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.

Title:Intramembrane-Cleaving Proteases (I-CLiPs)Format:PaperbackDimensions:142 pagesPublished:November 11, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048176042

ISBN - 13:9789048176045

Look for similar items by category:

Reviews

Table of Contents

Chapter 1: THE SITE-2 PROTEASE AT TEN, Robert B. Rawson and Wei-ping Li; Chapter 2: SIGNAL PEPTIDE PEPTIDASES, Todd E. Golde, Criag Zwizinski, Andrew Nyborg; Chapter 3: GXGD-TYPE INTRAMEMBRANE PROTEASES, Harald Steiner, Christian Haass; Chapter 4: RHOMBOID INTRAMEMBRANE SERINE PROTEASES, SINISA URBAN; Chapter 5: PROTEASES OF THE RHOMBOID FAMILY IN THE YEAST SACCHAROMYCES CEREVISIAE, Elke Pratje; Chapter 6: y-SECRETASE AND ALZHEIMER'S DISEASE, Michael S. Wolfe; Chapter 7: y-SECRETASE MEDIATED PROTEOLYSIS: AT THE CUTTING EDGE OF NOTCH SIGNALING, Ma. Xenia G. Ilagan, Dilip Chandu and Raphael Kopan; Index.