Introduction To Nuclear Mechanics And Genome Regulation by G.v. ShivashankarIntroduction To Nuclear Mechanics And Genome Regulation by G.v. Shivashankar

Introduction To Nuclear Mechanics And Genome Regulation

byG.v. Shivashankar

Paperback | October 1, 2018

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Introduction to Nuclear Mechanics and Genome Regulationpresents the first text to thoroughly explore the foundations of this exciting topic area, providing a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more.

With its practical approach and foundational focus, the book serves as a invaluable reference for students, researchers, and clinicians looking to understand this area of cutting-edge study.



  • Offers a thorough discussion of the biophysical principles underlying nuclear organization
  • Contains applied case studies and full color images that support concept illustration, making this an invaluable reference for students, researchers and clinicians
  • Features a diverse range of chapters covering the fundamentals of nuclear mechanics and genome regulation, including physico-chemical constraints in DNA
  • Introduces advanced biophysical methods, bio-imaging methods, and new molecular biology tools for studying nuclear structures
Dr. G. V. Shivashankar is currently the Deputy Director of Mechanobiology Institute, National University of Singapore. Shivashankar's laboratory is focused on understanding the role of cell geometry on nuclear mechanics and genome regulation in living cells using a multi-disciplinary approach. He carried out his PhD research at the Roc...
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Title:Introduction To Nuclear Mechanics And Genome RegulationFormat:PaperbackDimensions:200 pages, 9.41 × 7.24 × 0.98 inPublished:October 1, 2018Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128123451

ISBN - 13:9780128123454

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Table of Contents

1. Physico-chemical constraints in DNA
2. 3D organization of chromosomes and functional gene clusters
3. Spatial dimension to DNA transcription, replication, damage and repair
4. Dynamics within the nucleus and functional microrheology
5. Cytoskeleton to nuclear links and prestressed nuclear architecture
6. Nuclear mechanotransduction and genetic networks
7. Chromatin plasticity during differentiation, development and reprogramming
8. Mechanical homeostasis of the nucleus during cell division and migration
9. Nuclear mechanics in diseases and as diagnostic markers
10. Evolutionary constraints in DNA packing and genome regulation