Introduction to Peptides and Proteins by Ulo LangelIntroduction to Peptides and Proteins by Ulo Langel

Introduction to Peptides and Proteins

byUlo Langel, Benjamin F. Cravatt, Astrid Graslund

Hardcover | November 18, 2009

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Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research.

Introduction to Peptides and Proteinsbrings together some of the most respected researchers in protein science to present a remarkably coherent introduction to modern peptide and protein chemistry. The first sections of the book delve into ¿

  • Basic peptide and protein science from assembly through degradation

  • Traditional and emerging research methods including those used in bioinformatics and proteomics
  • New computational approaches and algorithms used to find patterns in the vast data collected by sequencing projects

After providing a foundation in tools and methods, the authors closely examine six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes. They concentrate on biochemical mechanisms and where possible indicate therapeutic or biotechnical possibilities.

Then focusing on clinical aspects, the authors investigate misfolding as found in prion diseases, miscleavage as found in Alzheimer¿s, and mis-sequencing as found with some cancers. Drawing from some of their own research, the authors summarize recent achievements and emerging applications. They discuss the use of proteins and peptides as drugs and the solid-phase synthesis required for drug production. They also look at the use of peptides as functional biomolecules and research tools.

No longer just the domain of biologists, many key advances in protein research started in physics labs and have involved contributions from a host of fields including statistics, drug development, genetics, and chemical spectroscopy.Introduction to Peptides and Proteinsprovides researchers across these fields with the thorough foundation needed to explore all the potential that protein research offers.

Title:Introduction to Peptides and ProteinsFormat:HardcoverDimensions:420 pages, 9.21 × 6.14 × 1.1 inPublished:November 18, 2009Publisher:Taylor and FrancisLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1420064126

ISBN - 13:9781420064124

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Table of Contents

Preface

Further Reading

Biography

Introduction to Part 1; Matja¿ Zorko

From Building Block to 3-D Structure

Amino Acids; Matja¿ Zorko

Noncovalent Interactions; Matja¿ Zorko

Structural Organization of Proteins; Matja¿ Zorko

Protein Biosynthesis and Posttranslational Modifications

The Biosynthesis of Proteins; Matja¿ Zorko

Posttranslational Modifications; Matja¿ Zorko

Folding of Proteins

Protein Folding; Matja¿ Zorko

Intracellular Sorting of Proteins; Gunnar von Heijne

Protein Degradation

Protein Turnover; Matja¿ Zorko

Introduction to Part II; Astrid Gr¿und

Purification and Characterization of Proteins; Matja¿ Zorko

Crystallography and X-Ray Diffraction Astrid Gr¿und

Optical Spectroscopy; Astrid Gr¿und

Nuclear Magnetic Resonance (NMR); Astrid Gr¿und

Methods to Follow Protein Folding; Astrid Gr¿und

Mass Spectrometry; Astrid Gr¿und

Chemical Synthesis of Peptides and Proteins; ¿o Langel

Introduction to Part III; Tiit Land

Protein Engineering and Gene Silencing; ¿o Langel

Protein¿Ligand Interactions; ¿o Langel

Sequence Analysis and Function Prediction; Tiit Land

Protein Structure Prediction; Tiit Land

Proteomics; Sherry Niessen and Benjamin F. Cravatt

Introduction to Part IV; ¿o Langel

Enzymes; Matja¿ Zorko

Nucleic Acid¿Binding Proteins; ¿o Langel

Cell Surface Receptors and Signaling; ¿o Langel

Membrane Proteins; Gunnar von Heijne

Antibodies; ¿o Langel

Fibrous Proteins; ¿o Langel

Selected Classes of Bioactive Peptides; ¿o Langel

Introduction to Part V; ¿o Langel and Astrid Gr¿und

Misfolding-Based Diseases; Astrid Gr¿und

Miscleavage-Based Diseases; Astrid Gr¿und

Missequence-Based Diseases; Astrid Gr¿und

Peptides and Proteins as Drugs; ¿o Langel