Ion Channel Pharmacology

Hardcover | January 1, 1998

EditorBernat Soria, Valentin Cena

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Molecular biology techniques have led to increased understanding of ion channel structure which has opened the way for the development of new drugs targeted at specific types of ion channels. This book aims to provide a fully comprehensive, single-volume overview of the effects of differentdrugs and toxins on ionic channels, with every chapter providing a detailed description of the pharmacology of each particular ion channel. It will be an essential reference tool for all researchers in this topical and fast-moving subject area.

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Molecular biology techniques have led to increased understanding of ion channel structure which has opened the way for the development of new drugs targeted at specific types of ion channels. This book aims to provide a fully comprehensive, single-volume overview of the effects of differentdrugs and toxins on ionic channels, with every...

Bernat Soria and Valentin Cena are both at Institute of Bioengineering and Institute of Neurosciences, Universidad Miguel Hernandez, Alicante, Spain.

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Format:HardcoverDimensions:486 pages, 9.45 × 6.61 × 1.18 inPublished:January 1, 1998Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198523602

ISBN - 13:9780198523604

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Table of Contents

Part I - DevelopmentF Giraldez: Ch 1 - Neurotrophic factors and development of ionic channels in primary sensory neurons on the earPart II - Sodium channelsT Narahashi: Ch 2 - Chemical modulation of sodium channelsJ Tamargo: Ch 3 - Antiarrhythmic action of drugs interacting with sodium channelsPart III - Calcium channelsE Carbone: Ch 4 - Biophysics of voltage-dependent Ca2+ channels: gating kinetics and their modulationB Bean: Ch 5 - Pharmacology of voltage-dependent calcium channelsH B Pollard: Ch 6 - Ion channels formed by amyloid B protein (ABP[1-40]). Pharmacology and therapeutic implications for Alzheimer's DiseasePart IV - Potassium channelsB Soria: Ch 7 - The biophysical basis of potassium pharmacologyM L Garcia: Ch 8 - Peptide toxins interacting with potassium channelsM J Dunne: Ch 9 - Properties of the ATP-refulated K+ channel in pancreatic B-cellsB Soria: Ch 10 - Potential role of the pharmacology of potassium channels in therapeuticsPart V - Chloride channelsM A Valverde: Ch 11 - Chloride channel pharmacologyPart VI - Mechano-gated channelsO P Hamill: Ch 12 - Drug effects on mechano-gated channelsPart VII - Intracellular channelsE Jaimovich: Ch 13 - Intracellular channels in muscleP G Kostyuk: Ch 14 - Basic properties of calcium release channels in neural cellsM-L Camp: Ch 15 - Mitochondrial membrane channels and their pharmacologyN Arispe: Ch 16 - Modulation of a large conductance K+ channel; from chromaffin granule membranes by adrenergic agonists and G-proteinsPart VIII - Cyclic nucleotide-gated channelsG Matthews: Ch 17 - Cyclic nucleotide gated ion channels. Physiology, pharmacology and molecular biologyPart IX - Receptor-operated channelsJ Lerma: Ch 18 - Excitatory animoacid-activated channelsP Stern and D Colquhoun: Ch 19 - Comparison of native and recombinant NMDA receptor channelsK T Layer: Ch 20 - A unified theory of antidepressant action: evidence for adaptation of the N-methyl-D-aspartate (NMDA) receptor following chronic antidepressant treatmentsO Krishtal: Ch 21 - Excitatory synaptic transmission in hippocampus: modulation by purinoceptors via Ca2+ channels