Ion Channels: From Structure to Function

Hardcover | October 24, 2009

EditorJames Kew, Ceri Davies

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Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness. Thus, billions of dollarshave been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts: Part one - an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterisation through to the deploymentof high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with eachchapter therein focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily.Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the physiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists as well as a highlyvaluable reference text for experienced researchers already working in the ion channel area.

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Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness. Thus, billions of dollarshave been, and still are being, invested in ...

James Kew received a degree in Biological Sciences from Exeter University in 1991 and a Ph.D. from Cambridge University in 1995. He joined F.Hoffmann-La Roche in Basel in 1995, first as a postdoctoral scientist and subsequently as head of an electrophysiology and cell biology laboratory. During this period his work focussed on the pha...
Format:HardcoverDimensions:568 pages, 10.87 × 8.62 × 0.1 inPublished:October 24, 2009Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199296758

ISBN - 13:9780199296750

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Table of Contents

Introduction1. Derek Tresize, Tim Dale and Martin Main: Introduction to Ion Channel Structure and FunctionPart I: Voltage Gated Ion Channels2.1. Bernardo Rudy: Voltage-Gated K+ channels2.2. Bernardo Rudy, Jonathon Maffie, Yimy Amarillo, Brian Clark, Hyo-Young Jeong, Illya Kruglikov, Elaine Kwon, Marcela Nadal and Edward Zagha: Kv1-Kv6 \ Kv8-Kv9 family2.3. Jonathan Robbins and Gayle Passmore: Kv7 family2.4. Matthew Perry and Michael Sanguinetti: Kv10-Kv12 families2.5. Dawon Kang and Donghee Kim: K2P families2.6. Joel Baumgart and Edward Perez-Reyes: Voltage-Gated Ca2+ Channels2.7. Sulayman Dib-Hajj and Tony Priestley: Voltage-Gated Na+ Channels2.8. Michael Pusch: Voltage-Gated Chloride Channels2.9. Mira Kuisle and Anita Luthi: Hyperpolarization-Activated ChannelsPart II: Extracellular Ligand-Gated Ion Channels3.1. Cys Loop Receptors3.2. Marzia Lecchi, Jean-Charles Hoda, Ronald Hogg and Daniel Bertrand: Nicotinic Acetylcholine Receptors3.3. John Peters, Michelle Cooper, Matthew Livesey, Jane Carland and Jeremy Lambert: 5-HT3 receptors3.4. Carmen Villmann and Cord-Michael Becker: Glycine Receptors3.5. Hans Mohler, Dietmar Benke Uwe Rudolph and Jean-Marc Fritschy: GABAA receptors3.6. Glutamate Receptors3.7. Laura Jane King, Hilary Jackson, Thomas Chater, Peter Hastie and Jeremy Henley: AMPA Receptors3.8. Sanja Selak, Rocio Rivera, Ana Paternain and Juan Lerma: Kainate Receptors3.9. Alasdair Gibb: NMDA Receptors3.10. ATP Receptors3.11. Iain Chessell and Anton Michel: P2X Receptors3.12. Others3.13. Eric Lingueglia and Michel Lazdunski: Acid Sensing Ion Channels (ASICs)3.14. Stephan Kellenberger and Laurent Schild: Epithelial Sodium ChannelsPart III: Intracellular Ligand-Gated Ion Channels4.1. Jorge Arreola, Juan Pablo Reyes, Teresa Rosales-Saavedra and Patricia Perez-Cornejo: Chloride Channels Activated by Intracellular Ligands4.2. Zhengchao Wang and Fangxiong Shi: Cyclic Nucleotide-Gated Cation Channels4.3. Morten Grunnet, Dorte Strobaek, Soren-Peter Olesen and Palle Christophersen: KCa1- KCa5 Families4.4. KIR family4.5. Hiroshi Hibino and Yoshihisa Kurachi: KIR1,2,4,5,7 families4.6. Atsushi Inanobe and Yoshihisa Kurachi: KIR3 family4.7. Christophe Moreau, Andre Terzic and Michel Vivaudou: KIR6 (KATP) family4.8. Stephan Lehnart and Andrew Marks: Ryanodine Receptors4.9. Randen Patterson: IP3 receptorPart IV: Polymodal Gated Ion Channels5.1. Grzegorz Owsianik, Thomas Voets and Bernd Nilius: Transient Receptor Potential Channels5.2. Elizabeth Hartfield, Annette Weil, James Uney and Eric Southam: Connexins - Gap Junctions