Ions in the Brain: Normal Function, Seizures, and Stroke

Hardcover | February 3, 2004

byGeorge G. Somjen

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Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effectedby the blood-brain barrier, and by membrane ion pumps and other transport mechanisms of neurons and glial cells. Normally adjusted for optimal neural function, ion levels can change and alter the excitability of neurons and influence synaptic transmission in healthy and diseased brains. After anintroduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugsare also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons forthe exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.

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Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effectedby the blood-brain barrier, and by membrane i...

George C. Somjen is at Duke University Medical Center.

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Format:HardcoverDimensions:504 pages, 6.42 × 9.21 × 1.42 inPublished:February 3, 2004Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195151712

ISBN - 13:9780195151718

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Table of Contents

PART I. IONS AND WATER IN THE BRAIN1. The blood-brain barrier2. The regulation of brain ions3. Osmotic stress and the brain4. The influence of ion concentrations on neuron functionPART II. CEREBRAL SEIZURES5. A primer of epileptiform seizures6. Experimental seizures7. Electrophysiology of seizures8. Ions and seizures9. Solving seizures by simulations10. Seizures, channels, genes11. Mechanisms of action of antiepileptic drugsPART III. SPREADING DEPRESSION OF LEAO12. Introduction to Spreading Depression. Extracellular electric signs13. Ion fluxes during Spreading Depression14. Membrane potential and input resistance during Spreading Depression15. The mechanism of Spreading Depression16. Solving the puzzle of Spreading Depression by computer simulationPART IV. PATHOLOGICAL BIOPHYSICS OF CEREBRAL HYPOXIA AND STROKE17. Hypoxia, asphyxia and ischemia18. The mechanism of early, reversible hypoxic synaptic failure19. Irreversible hypoxic (ischemic) neuron injury

Editorial Reviews

"This is an excellent book, which is a must read for all interested in the fields covered. Somjen sticks with the facts and describes in exquisite detail what happens when the brain malfunctions, which is surely how successful strategies for combating devastating neurological conditions willultimately be devised. A worthy testament to an exemplary scientific career."--Angus Brown