Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases: A New Perspective

Hardcover | April 1, 2009

byMaurice E. Langham

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From the introduction: "The purpose of the present book is to bring together in a coherent manner new knowledge gained from research over the past 50 years on the physiology of intraocular pressure, ocular blood flow and the relation of these fundamental parameters to early diagnosis and therapy of vascular diseases of the eye and brain. It will be evident to the reader that the presentation is influenced significantly by the author's own research. My justification is that by good fortune I have spent many years with superb collaboration helping solve outstanding problems of ocular physiology. This knowledge has increased understanding of the parameters underlying the onset of ischemia and the loss of autoregulation associated with common ocular disease and thereby led to new methods of diagnosis and therapy."

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From the Publisher

From the introduction: "The purpose of the present book is to bring together in a coherent manner new knowledge gained from research over the past 50 years on the physiology of intraocular pressure, ocular blood flow and the relation of these fundamental parameters to early diagnosis and therapy of vascular diseases of the eye and brai...

From the Jacket

Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases: A New Perspective presents evidence that ischemia and loss of autoregulation of blood flow are associated with the onset of the major ocular and cerebral diseases including macular degeneration, diabetic retinopathy, low and normal tension open angle glaucoma...

Format:HardcoverDimensions:211 pages, 10 × 7.01 × 0.27 inPublished:April 1, 2009Publisher:Springer New York

The following ISBNs are associated with this title:

ISBN - 10:0387097155

ISBN - 13:9780387097152

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Table of Contents

"In vivo" manometric measurements of the steady state Intraocular pressure and the IOP pulse in animals and man.- The rate of formation of the aqueous humor.- The steady state IOP/flow relations in dead and living animal and human eyes.- Homeostasis, autoregulation and relative ischemia.- The pressure/volume relation in eyes of dead and living animal and human eyes.- The ocular perfusion pressure and its influence on the IOP pulse.- Direct and indirect measurements of ocular blood flow in anesthetized and conscious animals and humans.- The morphology and hydrodynamics of the chamber angle.- The sympathetic nerve innervation of the eye and the actions of the adrenergic transmitter norepinephrine on IOP and ocular blood flow.- Manometric studies on the IOP and the vascular circulation in ophthalmic disease.- Indirect measurements of the IOP and the IOP pulse.- The effect of posture and corneal thickness on the IOP.- The Langham analogue and digitized pneumatic tonometers.- The calibration of the IOP and the IOP pulse using the Langham pneumatic tonometer.- The theory of the Langham tonometer.- The IOP/pulse amplitude relation in healthy animal and human eyes.- The IOP/PA relation and loss of autoregulation in ocular diseases including open angle glaucoma, low tension glaucoma, age related macular degeneration, diabetic retinopathy, and occlusion of the central retinal vein.- Autoregulation of the IOP and the ocular blood flow.- The evaluation of ocular ischemia and the loss of autoregulation for the early detection of ocular vascular diseases.- The action of ocular hypotensive drugs on ocular blood flow and on the IOP/PA relation.- The confluence and integration of therapies based on modulation of the IOP and ocular blood flow.- Longitudinal therapeutic studies.- The ophthalmic arterial pressure, the IOP/PA relations, and their association to the ocular and cerebral circulations.- Opthalmodynamometry.- Autoregulation of the IOP and blood flow in the human eye.- Objective measurements of the diastolic and systolic ophthalmic arterial pressures in man.- The ophthalmic arterial pressure in healthy subjects.- The relation between the ophthalmic arterial pressure and the IOP/PA relation.- Modulation of the IOP/PA relation in subjects with stenosis of the internal carotid artery.- Alzheimer's disease and the eye.- The ocular perfusion pressure and the visual threshold.- Concepts and new perspectives.- References.

Editorial Reviews

From the reviews:"This monograph is primarily an extensive review of the literature on intraocular pressure and any other pressures having to do with the eye. . A major value of this monograph is the wealth of primary citations to literature that predates PubMed. . this monograph could have used some anatomical figures and diagrams in the beginning chapters to go along with the physiological descriptions because the monograph is very approachable to interested readers who may not be currently working in the eye." (Joseph C. LaManna, Journal of Alzheimer's Disease, Vol. 18, 2009)"Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases: A New Perspective summarizes a life's work dedicated to understanding how a complex interaction of factors, such as intraocular pressures, ocular perfusion, and autoregulation affect ocular health. As such, this sole-authored text explores the . interests of most practicing ophthalmologists and neuroradiologists. . The illustrations, graphs, and line drawings have been carefully selected and help the author present a compelling story of the value of this approach to understanding the pathophysiology of ocular disease." (American Journal of Neuroradiology, September, 2009)