Jaspers Basic Mechanisms of the Epilepsies

Hardcover | June 14, 2012

EditorJeffrey Noebels, Massimo Avoli, Michael Rogawski

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H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "betterunderstanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind - assessing where epilepsy research has been, what it has accomplished,and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role ofinteractions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complexheredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate thediscoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in relateddisciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research inmolecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

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H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "betterunderstanding of the epilepsies and seek more rational m...

Dr. Jeffrey Noebels is Cullen Trust for Health Care Endowed Chair Professor of Neurology, Neuroscience, and Molecular and Human Genetics at Baylor College of Medicine. He is also Vice Chair for Research and Director of the Blue Bird Circle Developmental Neurogenetics Laboratory in the Department of Neurology. The focus of his research...

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Format:HardcoverDimensions:1160 pages, 10 × 7 × 0.98 inPublished:June 14, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199746540

ISBN - 13:9780199746545

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Table of Contents

Section I: Introduction1. The Next Decade of Research in the Basic Mechanisms of the Epilepsies2. Massimo Avoli: Herbert H. Jasper and the Basic Mechanisms of the Epilepsies3. Why - and how - do we approach basic epilepsy researchSection II: Fundamentals of neuronal excitability relevant to seizures and epilepsy4. Massimo Mantegazza and William A. Catterall: Voltage-gated Na+ Channels: Structure, Function, and Pathophysiology5. Edward C. Cooper: Potassium channels (including KCNQ) and epilepsy6. Stuart M Cain and Terrance P Snutch: Voltage-gated calcium channels in epilepsy7. Nicholas P. Poolos: Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channelopathy in epilepsy8. Enrico Cherubini: Phasic GABAA-mediated inhibition9. Matthew C Walker and Dimitri M Kullmann: Tonic GABAA receptor-mediated signaling in epilepsy10. Raymond Dingledine: Glutamatergic mechanisms related to epilepsy: ionotropic receptors11. Riccardo Bianchi, Robert K. S. Wong, and Lisa R. Merlin: Glutamate receptors in epilepsy: Group I mGluR-mediated epileptogenesis12. J. Victor Nadler: Plasticity of Glutamate Synaptic Mechanisms13. Igor Timofeev, Maxim Bazhenov, Jos.e Seigneur, Terrence Sejnowski: Neuronal synchronization and thalamocortical rhythms in sleep, wake and epilepsy14. John G R Jefferys, Premysl Jiruska, Marco de Curtis, Massimo Avoli: Limbic Network Synchronization and Temporal Lobe Epilepsy15. Hajime Takano and Douglas A. Coulter: Imaging of Hippocampal Circuits in Epilepsy16. Richard J. Staba: Normal and Pathologic High-Frequency Oscillations17. Marco de Curtis, John G R Jefferys, and Massimo Avoli: Interictal Epileptiform Disccharges in Partial Epilepsy: Complex Neurobiological Mechanisms Based on Experimental and Clinical Evidence18. Vincenzo Crunelli, Nathalie Leresche, and David W. Cope: Gaba-A Receptor Function in Typical Absence Seizures19. Hua A. Han, Miguel A. Cortez, and O. Carter Snead III: Gabab Receptor and Absence Epilepsy20. Carl L. Faingold: Brainstem networks: Reticulo-cortical synchronization in Generalized Convulsive Seizures21. John W. Swann and Solomon L. Moshe: On the Basic Mechanisms of Infantile Spasms22. Roger D. Traub, Miles A. Whittington, Mark O. Cunningham: Fast oscillations and synchronization examined with in vitro models of epileptogenesis23. Marianne J. Case, Robert J. Morgan, Calvin J. Schneider, Ivan Soltesz: Computer Modeling of EpilepsySection III - Mechanisms of seizures susceptibility and epileptogenesis24. David A. Prince, Isabel Parada, Kevin Graber: Traumatic brain injury and posttraumatic epilepsy25. Asla Pitk,nen and Tamuna Bolkvadze: Head Trauma and Epilespsy26. C.line M. Dub., Shawn McClelland, ManKin Choy, Amy L. Brewster, Yoav Noam, Tallie Z. Baram: Fever, febrile seizures and epileptogenesis27. Alon Friedman and Uwe Heinemann: Role of Blood-Brain Barrier Dysfunction in Epileptogenesis28. David C. Henshall and Brian S. Meldrum: Cell death and survival mechanisms after single and repeated brief seizures29. Jerome Niquet, Maria-Leonor Lopez-Meraz, Claude G. Wasterlain: Programmed Necrosis after Status Epilepticus30. Nihal C. de Lanerolle, Tih-Shih Lee, and Dennis D. Spencer: Histopathology of Human Epilepsy31. F. Edward Dudeka and Kevin J. Staley: The Time Course and Circuit Mechanisms of Acquired Epileptogenesis32. Paul S. Buckmaster: Mossy Fiber Sprouting in the Dentate Gyrus33. Yehezkel Ben-Ari: Kainate and Temporal Lobe Epilepsies: 3 decades of progress34. Robert S. Sloviter, Argyle V. Bumanglag, Robert Schwarcz, and Michael Frotscher: Abnormal dentate gyrus network circuitry in temporal lobe epilepsy35. Christophe Bernard: Alterations in synaptic function in epilepsy36. Charles E. Ribak, Lee A. Shapiro, Xiao-Xin Yan, Khashayar Dashtipour, J. Victor Nadler, Andre Obenaus, Igor Spigelman, and Paul S. Buckmaster: Seizure-induced formation of basal dendrites on granule cells of the rodent dentate gyrus37. Cha-Min Tang and Scott M. Thompson: Perturbations of Dendritic Excitability in Epilepsy38. Jack M. Parent and Michelle M. Kron: Neurogenesis and Epilepsy39. J.O. McNamara and H.E. Scharfman: Temporal Lobe Epilepsy and the BDNF Receptor, TrkB40. Carolyn R. Houser, Nianhui Zhang, and Zechun Peng: Alterations in the Distribution of GABAA Receptors in Epilepsy41. Suchitra Joshi and Jadeep Kapur: GABAA receptor plasticity during status epilepticus42. Istvan Mody: Plasticity of GABAA receptors relevant to neurosteroid actions43. Richard W. Olsen and Igor Spigelman: GABAA Receptor Plasticity in Alcohol Withdrawal44. Amy R. Brooks-Kayal, and Shelley J. Russek: Regulation of GABAA Receptor Gene Expression and Epilepsy45. Jerome Clasadonte and Philip G. Haydon: Astrocytes and Epilepsy46. Richard Miles , Peter Blaesse, Gilles Huberfeld , Lucia Wittner, and Kai Kaila: Chloride homeostasis and GABA signaling in temporal lobe epilepsy47. Christian Steinh,user, Gerald Seifert: Astrocyte dysfunction in epilepsy48. Annamaria Vezzani, Stephan Auvin, Teresa Ravizza, Eleonora Aronica: Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators49. Giuseppe Biagini, Carla Marinelli, Gabriella Panuccio, Giulia Puia, and Massimo Avoli: Glia-Neuron Interactions: Neurosteroids and Epileptogenesis50. Ruth Ottman: Gene Discovery in the Genetically Complex EpilepsiesSection IV - Epilepsy genes and development51. Thomas N. Ferraro, Dennis J. Dlugos, Hakon Hakonarson, Russell J. Buono: Strategies for Studying the Epilepsy Genome52. William A. Catterall: Sodium Channel Mutations and Epilepsy53. Robert Brenner and Karen S. Wilcox: Potassium Channelopathies of Epilepsy54. Jeffrey L. Noebels: The Voltage-Gated Calcium Channel and Absence Epilepsy55. Patrick Cossette, Pamela Lachance-Touchette, and Guy A. Rouleau: Mutated GABAA receptor subunits in idiopathic generalized epilepsy56. Steven Petrou and Christopher A. Reid: The GABAA?2(R43Q) mouse model of human genetic epilepsy57. Robert L. Macdonald, Jing-Qiong Kang, and Martin J. Gallagher: GABAA Receptor Subunit Mutations and Genetic Epilepsies58. Ortrud K. Steinlein, Sunao Kaneko, and Shinichi Hirose: Nicotinic acetylcholine receptor mutations59. Miriam H. Meisler, and Janelle E. O'Brien: Gene Interactions and Modifiers in Epilepsy60. Judy S. Liu, Christian R. Schubert, and Christopher A. Walsh: Rare genetic causes of lissencephaly may implicate microtubule-based transport in the pathogenesis of cortical dysplasias61. Diego M. Gelman, Oscar Mar!n, and John L. R. Rubenstein: The Generation of Cortical Interneurons62. Christel Depienne, Isabelle Gourfinkel-An, St.phanie Baulac, and Eric LeGuern: Genes in infantile epileptic encephalopathies63. Eric D. Marsh and Jeffrey A. Golden: Developing Models of Aristaless-related homeobox mutations64. Hirotomo Saitsu, Mitsuhiro Kato, and Naomichi Matsumoto: Haploinsufficiency of STXBP1 and Ohtahara syndrome65. Michael Wong and Peter B. Crino: mTOR and Epileptogenesis in Developmental Brain Malformations66. Deb K Pal and David A Greenberg: Major Susceptibility Genes for Common Idiopathic Epilepsies: ELP4 in Rolandic Epilepsy and BRD2 in Juvenile Myoclonic Epilepsy67. T. Grisar, B. Lakaye, L de Nijs, J. LoTurco, A. Daga , and A.V. Delgado-Escueta: Myoclonin1/EFHC1 in cell division, neuroblast migration, synapse/dendrite formation in juvenile myoclonic epilepsy68. Jos. M. Serratosa, Berge A. Minassian B, and Subramaniam Ganesh: Progressive myoclonus epilepsy of Lafora69. Anna-Elina Lehesjoki and Mark Gardiner: Progressive myoclonus epilepsy: Unverricht-Lundborg disease and Neuronal ceroid lipofuscinoses70. Miyabi Tanaka, Timothy M. DeLorey, Antonio V. Delgado-Escueta, and Richard W. Olsen: GABRB3, Epilepsy, and Neurodevelopment71. Carl E. Stafstrom, Paul J. Hagerman, and Isaac N. Pessah: Pathophysiology of Epilepsy in Autism Spectrum Disorders72. Jonathan K. Kleen, Rod C. Scott, Pierre-Pascal Lenck-Santini, and Gregory L. Holmes: Cognitive and Behavioral Co-Morbidities of Epilepsy73. Michael A. Rogawski: Migraine and Epilepsy-Shared Mechanisms within the Family of Episodic DisordersSection V - Epilepsy therapeutics74. Raman Sankar, and Andrey Mazarati: Neurobiology of Depression as a Comorbidity of Epilepsy75. Annette C Dolphin: Calcium channel 2 subunits in epilepsy and as targets for antiepileptic drugs76. Rafal M. Kaminski, Michel Gillard, and Henrik Klitgaard: Targeting SV2A for Discovery of Antiepileptic Drugs77. Doodipala Samba Reddy and Michael A. Rogawski: Neurosteroids - Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy78. Susan A. Masino and Jong M. Rho: Mechanisms of Ketogenic Diet Action79. Kevin D. Graber and Robert S. Fisher: Deep Brain Stimulation for Epilepsy: Animal Models80. H. Steve White: Animal Models for Evaluating Antiepileptogenesis81. Wolfgang L"scher: Strategies for antiepileptogenesis: Antiepileptic drugs versus novel approaches evaluated in post-status epilepticus models of temporal lobe epilepsy82. Kristopher T. Kahle and Kevin J. Staley: Neonatal Seizures and Neuronal Transmembrane Ion Transport83. Heinz Beck and Yoel Yaari: Antiepileptogenesis, Plasticity of AED Targets, Drug resistance, and Targeting the Immature Brain84. Ashok K. Shetty: Neural Stem Cell Therapy for Temporal Lobe Epilepsy85. Janice R. Naegele, Mohan C. Vemuri, and Lorenz Studer: Embryonic Stem Cell Therapy for Intractable Epilepsy86. Stewart A. Anderson and Scott C. Baraban: Cell Therapy Using GABAergic Neural Progenitors87. Jean-Bernard Manent and Joseph LoTurco: Reversing Disorders of Neuronal Migration and Differentiation in Animal Models88. Francesco M. Noe', Andreas T. Sorensen, Merab Kokaia, and Annamaria Vezzani: Gene therapy of focal onset epilepsy using adeno-associated virus vector-mediated overexpression of neuropeptide Y89. Detlev Boison: Adenosine Augmentation Therapy