Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience

byZvi LaronEditorJ. Kopchick

Hardcover | December 16, 2010

Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental Experience by Zvi Laron
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Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
Title:Laron Syndrome - From Man to Mouse: Lessons from Clinical and Experimental ExperienceFormat:HardcoverProduct dimensions:531 pages, 10.24 X 7.6 X 0 inShipping dimensions:531 pages, 10.24 X 7.6 X 0 inPublished:December 16, 2010Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642111823

ISBN - 13:9783642111822

Appropriate for ages: All ages

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