Left-Right Asymmetry in Vertebrate Development by M.L. López-GraciaLeft-Right Asymmetry in Vertebrate Development by M.L. López-Gracia

Left-Right Asymmetry in Vertebrate Development

byM.L. López-Gracia, M.A. Ros

Paperback | December 11, 2006

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Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline.

The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway.

Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.

Title:Left-Right Asymmetry in Vertebrate DevelopmentFormat:PaperbackDimensions:126 pagesPublished:December 11, 2006Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3540363475

ISBN - 13:9783540363477

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Table of Contents

Introduction.- Establishment of left-right asymmetry.- Signaling pathways with a predominant role in left-right patterning.- Mouse models of laterality.- Genetics of human alterations of organ situs.- Concluding remarks.- Annex.- Glossary.- References.- Subject index.