Linkage Thermodynamics of Macromolecular Interactions

Hardcover | May 20, 1998

byEnrico RichardsEditorDavid S. Eisenberg, Peter S. Kim

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This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

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This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the to...

Format:HardcoverDimensions:473 pages, 9 × 6 × 0.98 inPublished:May 20, 1998Publisher:Academic Press

The following ISBNs are associated with this title:

ISBN - 10:0120342510

ISBN - 13:9780120342518

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Table of Contents

M. Schaefer, H. van Vlijmen, and M. Karplus, Electrostatic Contributions to Molecular Free Energies in Solution.
E. Di Cera, Site-Specific Analysis of Mutational Effects in Proteins.
S.J. Edelstein and J.-P. Changeux, Allosteric Transitions of the Acetylcholine Receptor.
G.K. Ackers, Deciphering the Molecular Code of Hemoglobin Allostery.
E. Freire, Statistical Thermodynamic Linkage between Conformational and Binding Equilibria.
M.T. Record, Jr., W. Zhang, and C.F. Anderson, Analysis of the Effects of Salts and Uncharged Solutes on Protein and Nucleic Acid Equilibria and Processes: A Practical Guide to Recognizing and Interpreting Polyelectrolyte Effects, Hofmeister Effects, and Osmotic Effects of Salts.
S.N. Timasheff, Control of Protein Stability and Reactions by Weakly Interacting Cosolvents: The Simplicity of the Complicated.
Author Index.
Subject Index.

Editorial Reviews

Praise for the Volume"The contributions are by outstanding investigators who bring both a traditional perspective on this topic and expertise and knowledge in newer aspects and applications, such as protein-nucleic acid interactions...any investigator with interests in protein folding and stability, or protein-protein or protein-ligand interaction thermodynamics or in enzyme or receptor interaction thermodynamics should find this volume useful and informative... This volume is highly recommended for protein chemists, molecular or cell biologists who need a better understanding of these topics."--DOODY'S PUBLISHING REVIEWS (4 star rating)Praise for the Series"The authority, originality, and editing of the reviews are first class."--NATURE"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY