Long-term Potentiation: Enhancing neuroscience for 30 years by Timothy BlissLong-term Potentiation: Enhancing neuroscience for 30 years by Timothy Bliss

Long-term Potentiation: Enhancing neuroscience for 30 years

EditorTimothy Bliss, Graham Collingridge, Richard Morris

Hardcover | March 9, 2005

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In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP isthought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actualneural mechanism used by the brain to store information? This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research thatcover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today. Advance praise for Long Term Potentiation: "This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field." Colin Blakemore, University of Oxford
Timothy Bliss is at Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London. Graham Collingridge is at MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol.
Title:Long-term Potentiation: Enhancing neuroscience for 30 yearsFormat:HardcoverDimensions:420 pages, 9.45 × 6.61 × 1.13 inPublished:March 9, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198530307

ISBN - 13:9780198530305

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Table of Contents

T Bliss, G Collingridge and R Morris: IntroductionForeword by Colin BlakemoreHistory1. P Andersen: A prelude to long-term potentiation2. T Lomo: The discovery of long-term potentiation3. T Bliss: A journey from neocortex to hippocampus4. G Lynch: Long-term potentiation in the Eocene5. B McNaughton: Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history6. G Collingridge: The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation7. R Morris: Long-term potentiation and memoryInduction8. M Bear: Bidirectional synaptic plasticity: from theory to reality9. Z Bortolotto, S Lauri, J Isaac and G Collingridge: Kainate receptors and the induction of mossy fibre long-term potentiation10. D Johnston, B Christie, A Frick, R Gray, D Hoffman, L Schexnayder, S Watanabe and L-L Yuan: Active dendrites, potassium channels and synaptic plasticityExpression11. M Errington, P Galley and T Bliss: Long-term potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in extracellular glutamate: real-time measurements using a novel dialysis electrode12. T Hosokawa, M Ohta, T Saito and A Fine: Imaging spatio-temporal patterns of long-term potentiation in mouse hippocampus13. S Choi, J Klingauf and R Tsien: Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation14. R Malinow: AMPA receptor trafficking and long-term potentiation15. F Duprat, M Daw, W Lim, G Collingridge and J Isaac: GluR2 protein-protein interactions and the reulation of AMPA receptors during synaptic plasticity16. R Nicoll: Expression mechanisms underlying long-term potentiation: a postsynaptic view17. D Kullmann: Silent synapses: what are they telling us about long-term potentiation?Persistence18. W Abraham: How long will long-term potentiation last?19. K Harris, J Fiala and L Ostroff: Structural changes at dendritic spine synapses during long-term potentiation20. E Schuman and S Murase: Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions21. C Pittenger and E Kandel: In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampusFunction22. C Barnes: Long-term potentiation and the ageing brain23. R Morris, E Moser, G Riedel, S Martin, J Sandin, M Day and C O'Carroll: Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory24. S Tonegawa, K Nakazawa and M Wilson: Genetic neuroscience of mammalian learning and memory25. G Hedou and I Mansuy: Inducible molecular switches for the study of long-term potentiation26. B Bozon, A Kelly, S Josselyn, A Silva, S Davis and S Laroche: MAPK, CREB and zif268 are all required for the consolidation of recognition memoryNew Directions27. M Thomas and R Malenka: Synaptic plasticity in the mesolimbic dopamine system28. M Rowan, I Klyubin, W Cullen and R Anwyl: Synaptic plasticity in animal models of early Alzheimer's disease29. J Lisman: Long-term potentiation: outstanding questions and attempted synthesis