Macro Roles for MicroRNAs in the Life and Death of Neurons by Bart De StrooperMacro Roles for MicroRNAs in the Life and Death of Neurons by Bart De Strooper

Macro Roles for MicroRNAs in the Life and Death of Neurons

byBart De Strooper

Paperback | March 1, 2012

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biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents Pro?lingthemicroRNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 KennethS. Kosik,ThalesPapagiannakopoulos,NaXu, KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye TheWideVarietyofmiRNAExpressionPro?les intheDevelopingandMatureCNS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 DavidJ. Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons . . . . . . . . . 27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs . . . . . . . . . . . . 35 GerhardM. Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 KeithSzulwach,ShuangChang,andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 StephenM. Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 NancyM. Bonini microRNAsinSporadicAlzheimer'sDiseaseandRelated Dementias . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 Se´bastienS. He´bert,WimMandemakers,AikateriniS. Papadopoulou, andBartDeStrooper microRNADysregulationinPsychiatricDisorders . . . . . . . . . . . . . . . . . . . . . . . . 99 BinXu,JosephA. Gogos,andMariaKarayiorgou Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Contributors Abeliovich Asa Columbia University Medical Center, 630 West 168th Street, Room15-405,NewYork,NY10032,USA,aa900@columbia. edu Abu-ElneelKawther NeuroscienceResearchInstitute,DepartmentofMolecular CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA BoniniNancyM. UniversityofPennsylvania,306LeidyLaboratories,Depa- mentofBiology,Philadelphia,PA19104,USA,nbonini@sas. upenn. edu Chang Shuang Department of Human Genetics, Emory University School of Medicine,Atlanta,GA30322,USA CohenStephenM. TemasekLifeSciencesLaboratoryLimited,1ResearchLink National University of Singapore, 117604 Singapore, SINGAPORE, steve@ tll. org. sg DeStrooperBart Centerforhumangenetics,K. U. LeuvenandDepartmentof molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM GogosJosephA. DepartmentofPhysiology&CellularBiophysicsandDepa- mentofNeuroscience,ColumbiaUniversity,NewYork,USA He´bert Se´bastien S. Centre de Recherche du CHUQ (CHUL), Axe Neur- ciences,Universite´Laval,De´partementdeBiologieme´dicale,2705Boul. Laurier, LocalRC-9800,Que´bec,Qc,Canada,sebastien. hebert@crchul. ulaval. ca JinPeng DepartmentofHumanGeneticsandGraduatePrograminGeneticsand MolecularBiology,EmoryUniversitySchoolofMedicine,Atlanta,GA30322, USA,pjin@genetics. emory. edu ´ ´ ´ ´ KapsimaliMarika INSERMU784,GenetiqueMoleculaireduDeveloppement, ´ Ecole Normale Superieure, 46 rue d´Ulm, 75230 PARIS Cedex 05 FRANCE, kapsimal@biologie. ens. fr xi xii Contributors Karayiorgou Maria Columbia University, Department of Psychiatry, 1051 RiversideDrive,Unit#28,NewYorkNY10032,USA,mk2758@columbia. edu Kosik Kenneth S. Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, BiologyII,Room6139A,SantaBarbara,CA93106,USA,kosik@lifesci. ucsb.
Title:Macro Roles for MicroRNAs in the Life and Death of NeuronsFormat:PaperbackDimensions:121 pagesPublished:March 1, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:364226204X

ISBN - 13:9783642262043

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Table of Contents

Profiling the microRNAs by Kenneth S. Kosik, Thales Papagiannakopoulos, Na Xu, Kawther Abu-Elneel, Tsunglin Liu and Min Jeong Kye.- The Wide Variety of miRNA Expression Profiles in the Developing and Mature CNS by Marika Kapsimali.- Interactions Between microRNAs and Transcription Factors in the Development and Function of the Nervous System by David J. Simon.- A microRNA Feedback Circuit in Midbrain Dopamine Neurons by Asa Abeliovich.- Fine-Tuning mRNA Translation at Synapses with microRNAs by Gerhard M. Schratt.- Neuronal P-bodies and Transport of microRNA-Repressed mRNAs by Florence Rage.- Crosstalk between microRNA and Epigenetic Regulation in Stem Cells by Keith Szulwach, Shuang Chang and Peng Jin.- microRNAs in CNS Development and Neurodegeneration: Insights from Drosophila Genetics by Stephen M. Cohen.- Drosophila as a Model for Neurodegenerative Disease: Roles of RNA Pathways in Pathogenesis by Nancy M. Bonini.- MicroRNAs in Sporadic Alzheimer's Disease and Related Dementias by Sébastien S. Hébert, Wim Mandemakers, Aikaterini S. Papadopoulou and Bart De Strooper.- microRNA Dysregulation in Psychiatric Disorders by Bin Xu, Joseph A. Gogos and Maria Karayiorgou.- Subject Index.