Mass Spectrometry For The Clinical Laboratory

Hardcover | November 21, 2016

byHari NairEditorWilliam Clarke

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Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry , the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays therapeutic drugs, Vitamin D, hormones, etc. . Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

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Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate i...

Dr. Nair received his PhD in 1998 under the advice of Prof. Vicki Wysocki at Virginia Commonwealth University, Richmond, VA with specialization in the study of gas phase dissociation of biomolecules in a mass spectrometer. Since then after an NRC postdoctoral fellowship at the US Army, Aberdeen Proving Grounds, MD he has worked for ove...

other books by Hari Nair

Format:HardcoverDimensions:296 pages, 9.41 × 7.24 × 0.98 inPublished:November 21, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128008717

ISBN - 13:9780128008713

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Table of Contents

1. Mass spectrometry in clinical lab: determining the need and avoiding pitfalls

2. Application specific implementation of mass spectrometry platform

3. Sample preparation techniques for mass spectrometry in clinical lab:

4. Design of Validation and QC and Compliance

5. Best Practices for routine operation of clinical mass spectrometry assays

6. Toxicology: LCMS

7. Toxicology: GCMS

8. Therapeutic drug monitoring

9. Vitamin D and analogs

10. Steroid hormones

11. Thyroid hormones

12. Bacterial identification: MALDI TOF

13. High Resolution Accurate Mass (HRAM) Mass Spectrometry

14. Evolving platforms for clinical mass spectrometry (POCT, paper spray, TOF, etc)