Matrix Metalloproteinases and TIMPs

Paperback | January 15, 2000

byJ. Frederick Woessner, Hideaki Nagase

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The matrix metalloproteinases (MMPs) are a large family of enzymes that break down different components of the extracellular matrix. Their catalytic activity is dependent on the metal ion zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures,activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases(TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the four known TIMPs. Matrix metalloproteinases and TIMPs will therefore be an invaluable source of data for all researchers interested in MMPs and TIMPS.

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The matrix metalloproteinases (MMPs) are a large family of enzymes that break down different components of the extracellular matrix. Their catalytic activity is dependent on the metal ion zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures,activation, protein substrates, specificity re...

Fred Woessner is at University of Kansas Medical Center. Hideaki Nagase is at University of Miami School of Medicine.
Format:PaperbackPublished:January 15, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198502680

ISBN - 13:9780198502685

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Table of Contents

Abbreviations; Introduction; MMP sequences; TIMP sequences; Three dimensional structures of the MMPs and TIMPs; Activation of the zymogen forms of MMPs; Protein substrates of the MMPs; Specificity requirements of the MMPs; Inhibition of the MMPs; Biological roles of the MMPs; Functions of the TIMPs;Bibliography; Protein sequence alignments