Mechanics and Energetics of the Myocardium by Christian J.F. HolubarschMechanics and Energetics of the Myocardium by Christian J.F. Holubarsch

Mechanics and Energetics of the Myocardium

byChristian J.F. Holubarsch

Paperback | October 30, 2012

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During several decades of this century, the classical physiological studies on the cardiovascular system have greatly improved our knowledge on the function of this system under normal and pathological conditions. This knowledge was the basis of the breakthrough for diagnostic techniques like the Swan-Ganz catheter, coronary arteriography, left and right heart biopsies, and invasive measurements of contractility, as well as therapeutic tools including aortocoronary bypass surgery, percutanous transluminal coronary angioplasty, and a broad field of pharmacological interventions for the whole spectrum of cardiovascular diseases, especially chronic heart failure.
It was during the last decade that the scientific world focused on the evolution of molecular biology of the cardiovascular system so that cardiovascular physiology seemed to become less important. Regarding the myocardium, molecular alterations of important functional proteins (phenotype changes), as well as signal transduction pathways of contractility and cardiac growth have been elucidated. The functional importance of a number of genes has undoubtedly been proven with the help of transgenic animals.
Mechanics and Energetics of the Myocardiumprovides an overview for those researchers and practioners interested in the broad field of molecular biology and physiology of the cardiovascular system.
Title:Mechanics and Energetics of the MyocardiumFormat:PaperbackDimensions:216 pagesPublished:October 30, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1461352843

ISBN - 13:9781461352846

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Table of Contents

Preface. 1. Historical Aspects: The Frank-Starling Mechanism. 2. The Myothermal Method: Historical and Personal Aspects. 3. Papillary Muscle Experiments. 4. The Myothermal Approach. 5. Skinned Fiber Experiments. 6. The Frequency Response Method. 7. Single Cell Experiments. 8. Diastolic Compliance. 9. The PVA-concept. 10. Human Studies in vivo.