Mechanisms in Myeloid Tumorigenesis 1988: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March by Grace L.C. Shen-OngMechanisms in Myeloid Tumorigenesis 1988: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March by Grace L.C. Shen-Ong

Mechanisms in Myeloid Tumorigenesis 1988: Workshop at the National Cancer Institute, National…

byGrace L.C. Shen-OngEditorMichael Potter, Neal G. Copeland

Paperback | December 27, 2011

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Through numerous discussions with colleagues it became apparent that the time was right to begin a series of workshop-like meetings on myeloid tumorigenesis. Myeloid tumors are the nonlymphocytic tumors of the hematopoietic system which include tumors of the neutrophilic, monocytic, erythrocytic, basophilic (mast cell) and megakaryocytic lineages. Pioneering studies in myeloid tumorigenesis were initially made in chickens with the discovery of retroviruses that induce various kinds of myeloid tumors acutely (myelocytomatosis, myeloblastosis, and erythroblastosis). These avian retroviruses were subsequently shown to contain the oncogenes v-myb, v-<_2c_><_2c_20_v-erba2c_20_or20_v-erbb.20_there20_have20_been20_dramatic20_advances20_in20_studying20_the20_pathogenesis20_of20_hematopoietic20_tumors20_in20_genetically20_defined20_mammalian20_systems.20_many20_of20_the20_well20_developed20_model20_systems20_in20_inbred20_mice2c_20_have20_focused20_on20_t-20_and20_b-1ymphoma20_development.20_although20_myeloid20_tumors20_have20_been20_found20_in20_mice2c_20_they20_have20_not20_been20_studied20_as20_intensively20_as20_lymphoid20_tumors.20_possibly20_this20_is20_because20_myeloid20_tumors20_are20_less20_common20_than20_lymphoid20_tumors.20_recently2c_20_there20_has20_been20_renewed20_interest20_in20_murine20_myeloid20_tumor20_systems.20_this20_focus20_has20_resulted20_from20_129_20_the20_discovery20_of20_inbred20_strains20_of20_mice20_28_e.20_g.20_bxh-22c_20_akxd-20_232c_20_sjl2f_j29_20_that20_are20_highly20_susceptible20_to20_spontaneous20_or20_induced20_myeloid20_tumorigenesis3b_20_229_20_establishment20_of20_transplantable20_murine20_myeloid20_tumors20_28_e. _v-erba2c_="" or="" v-erbb.="" there="" have="" been="" dramatic="" advances="" in="" studying="" the="" pathogenesis="" of="" hematopoietic="" tumors="" genetically="" defined="" mammalian="" systems.="" many="" well="" developed="" model="" systems="" inbred="" _mice2c_="" focused="" on="" t-="" and="" b-1ymphoma="" development.="" although="" myeloid="" found="" they="" not="" studied="" as="" intensively="" lymphoid="" tumors.="" possibly="" this="" is="" because="" are="" less="" common="" than="" _recently2c_="" has="" renewed="" interest="" murine="" tumor="" focus="" resulted="" from="" _129_="" discovery="" strains="" mice="" _28_e.="" g.="" _bxh-22c_="" akxd-="" _232c_="" _sjl2f_j29_="" that="" highly="" susceptible="" to="" spontaneous="" induced="" _tumorigenesis3b_="" _229_="" establishment="" transplantable="">
Title:Mechanisms in Myeloid Tumorigenesis 1988: Workshop at the National Cancer Institute, National…Format:PaperbackDimensions:172 pages, 24.4 × 17 × 0.07 inPublished:December 27, 2011Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:364274625X

ISBN - 13:9783642746253

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Table of Contents

I. Classification of myeloid tumors.- The Pathology of Murine Myelogenous Leukemias.- II. Specific Chromosomal Abnormalities in Human and Murine Myeloid Hematologic Malignancies.- Chromosomal Abnormalities in Myeloid Hematologic Malignancies.- Radiation Induced Deletion of Chromosome 2 in Myeloid Leukemogenesis.- III. Disruption of "Oncogenes" by Virus Insertion in Murine Myeloid Tumorigenesis.- Recombinant Inbred Mouse Strains: Models for Studying the Molecular Genetic Basis of Myeloid Tumorigenesis.- Mechanisms in the Transformation of IL3-Dependent Hematopoietic Stem Cells.- Alternate Forms of MYB: Consequences of virus insertion in myeloid tumorigenesis and alternative splicing in normal development.- IV. Myeloid Leukemogensis Induced by Acute Transforming Virus Constructs in In Vitro and In Vivo Model Systems.- Retrovirus-induced Tumors Whose Developemnt is Facilitiated by a Chronic Immune Response: A Comparison of Two Tumors Committed to the Monocytic Lineage.- Studies of Secondary Transforming Events in Murine c-myc Retrovirus-Induced Monocyte Tumors.- Analysis of the Leukaemogenic Properties of the bcr-v-abl and GM-CSF Genes Using a New Retroviral Vector.- Biological effects of retroviral transfection of the murine Interleukin-3 gene into FDCP-Mix cells.- Conversion of Factor-Dependent Myeloid Cells to Factor Independence: Autocrine Stimulation is Not Coincident with Tumorigenicity.- V. Specific Genes Involved in Myeloid Tumorigenesis.- Biosynthesis of Macrophage Colony-Stimulating Factor (CSF-1): Differential Processing of CSF-1 Precursors Suggests Alternative Mechanisms for Stimulating CSF-1 Receptors.- The ets Family of Genes: Molecular Biology & Functional Implications.- VI. Proposed Mechanisms in Myeloid Tumorigenesis.- Adhesive Defects in Chronic Myeloid Leukaemia.- Induction of Leukemia by Avian Myeloblastosis Virus: A Mechanistic Hypothesis.- Role of Biologic Response Modifiers in the Growth and Differentiation of Myeloid Leukemic Cells.