Mechanisms of Cortical Development

Hardcover | April 1, 2000

byDavid Price, David Willshaw

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This is the first book that attempts to bring together what is known about the fundamental mechanisms that underlie the development of the cortex in mammals. Ranging from the emergence of the forebrain from the neural plate to the functioning adult form, the authors draw on evidence fromseveral species to provide a detailed description of processes at each stage. Where appropriate, evidence is extrapolated from non-mammalian species to generate hypotheses about mammalian development. In contrast to other texts of developmental biology, Mechanisms of Cortical Developmentintegrates information on regulatory processes at the levels of molecules, cells and metworks. The authors draw together an extensive literature on cellular development and structural morphology, biochemical and genetic events and hypotheses that have been subject to mathematical modelling.Important metholdogies, such as transgenics and formal modelling, are explained for the non-specialist. Major future challenges are clearly identified. This is a unique contribution to the literature, combining the fundamentals of experimental developmental neurobiology with accessible neuralmodelling. It will be essential reading for neuroscientists in general as well as those with a particular interest in development.

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This is the first book that attempts to bring together what is known about the fundamental mechanisms that underlie the development of the cortex in mammals. Ranging from the emergence of the forebrain from the neural plate to the functioning adult form, the authors draw on evidence fromseveral species to provide a detailed descriptio...

David Price is at University of Edinburgh. David Willshaw is at University of Edinburgh.

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Format:HardcoverPublished:April 1, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019262427X

ISBN - 13:9780192624277

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Table of Contents

Chapter 1 - IntroductionChapter 2 - Early development of the telencephalonChapter 3 - Molecular recognition of early forebrain and cortical developmentChapter 4 - Guidance of axons and innervation of cortical structuresChapter 5 - Map formationChapter 6 - Mechanisms controlling the development of cortical connections at the targetChapter 7 - Functional development of the cortexGlossary

Editorial Reviews

'eminently useful to specialists and students of neuroscience alike, especially given its unique perspective which reflecting the expertise of the authors, includes both biology and biological modeling' British Neuroscience