Mechanisms of Synaptic Transmission: Bridging the Gaps (1890-1990)

Hardcover | July 15, 2001

byJoseph D. Robinson

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Synaptic transmission plays a central role in the nervous system as the mechanism that allows for chemical and electrical communication between cells and thus connects discrete elements into the functioning whole. This is a broad account of anatomical, biochemical, embryological, medical,pathological, pharmacological, and physiological studies on synaptic transmission during the hundred years beginning in 1890. During this century, the process of synaptic transmission came to be recognized not only as the most fundamental neurophysiological process, but also as a seat ofpathological changes, and as the predominant site of action for drugs used to treat a wide range of psychiatric and neurological disorders. At the same time, research from these various disciplines was transformed into a new and unifying field, neuroscience. The course of these investigationsreveals ingenious experiments, powerful new techniques, and imaginative insights. The author describes broadly who did what, when, where, and how (and, in cases where it is apparent, why) and uses experimental results and interpretations to display the evolutionary course to our currentunderstanding of how nerve cells communicate: the basic principle of neural functioning. The book will be of interest to basic and clinical neuroscientists, pharmacologists, and physiologists, to historians and philosophers of the life sciences and medicine, and to their respective students.

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Synaptic transmission plays a central role in the nervous system as the mechanism that allows for chemical and electrical communication between cells and thus connects discrete elements into the functioning whole. This is a broad account of anatomical, biochemical, embryological, medical,pathological, pharmacological, and physiological...

Joseph D. Robinson is at State University of New York at Syracuse.

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Format:HardcoverDimensions:472 pages, 9.09 × 5.98 × 1.42 inPublished:July 15, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195137612

ISBN - 13:9780195137613

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Table of Contents

1. Beginnings: Cajal and the Neuron Theory (1889-1909)2. Beginnings: Sherrington and the Synapse (1890-1913)3. Chemical Transmission at Synapses (1895-1945)4. Chemical Transmission at Synapses (1945-1965)5. Identifying Neurotransmitters: (1946-1976)6. Characterizing Receptors (1905-1983)7. Second Messengers (1951-1990)8. Receptor Structures and Receptor Families (1983-1990)9. Synthesis, Storage, Transport, and Metabolic Degradation of Neurotransmitters10. Neurotransmitter Release11. Formation of Specific Synapses12. Learning13. Diseases and Therapies14. Epilogue