Mechanoreceptors: Their Functional Organization by George N. AkoevMechanoreceptors: Their Functional Organization by George N. Akoev

Mechanoreceptors: Their Functional Organization

byGeorge N. Akoev, T.A. Ganf, Boris V. Krylov

Paperback | December 6, 2011

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This volume on the processes of transformation of mechanical stimuli into electrical activity in various mechanoreceptors comprises the authors` investigations as well as relevant literature data. It deals mainly with initial electrical processes from stimulus of the mechanoreceptor to receptor potential. For the first time the connection between passive and active ion transport and the generation of electrical potentials is considered in detail. Furthermore, data on the properties and selectivity of different types of mechanosensitive ion channels, as well as results of morphological experiments on characteristics of the mechanosensitive membrane, and the changes during the activation of primary and secondary mechanoreceptors are discussed. This comprehensive overview is of interest to molecularbiologists, neuroscientists and biophysists.
Title:Mechanoreceptors: Their Functional OrganizationFormat:PaperbackDimensions:197 pagesPublished:December 6, 2011Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642729371

ISBN - 13:9783642729379

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Table of Contents

1 Some Morphological and Physicochemical Pecularities of Receptive Structures and the Accessory Apparatus of Mechanoreceptors.- 1.1 An External Characteristic of the Mechanoreceptor Field.- 1.1.1 Mechanoreceptors Formed by Afferent Nerve Fibers.- 1.1.2 Hair-ciliate Mechanoreceptors.- 1.2 Intracellular Organization of the Mechanoreceptor Region.- 1.2.1 The Mechanoreceptor Membrane.- 1.2.2 Mitochondria.- 1.2.3 Microtubules.- 1.2.4 Vesicles.- 1.3 A Characteristic of the Medium Surrounding Mechanoreceptors.- 1.4 A Brief Conclusion.- 2 A General Characteristic of Mechanoreceptor Activity.- 2.1 Receptor and Generator Potentials.- 2.2 Electrical Characteristics of the Receptor Potential.- 2.2.1 Muscle Spindles and the Pacinian Corpuscles.- 2.2.2 Crustacean Stretch Receptors.- 2.2.3 Hair Cells of the Acousticolateral System and Protozoan Mechanoreceptors.- 2.2.4 Arthropod Hair Mechanoreceptors.- 2.3 Electrical Responses of Nerve and Muscle Fibers to Mechanical Stimulation.- 2.4 Dependence of Receptor Potential Parameters upon Mechanical Stimulus Characteristics.- 2.4.1 Amplitude Reception.- 2.4.2 Stimulus Gradient Reception.- 2.4.3 Reception of Stimulus Sequence.- 2.4.4 Reception of Stimulus Duration and Adaptation of Mechanoreceptors.- 2.5 A Brief Conclusion.- 3 The Ionic Mechanisms of Receptor Potential Generation.- 3.1 The Role of Passive Ion Transport in Receptor Potential Generation.- 3.1.1 Sodium Ions.- 3.1.2 Potassium Ions.- 3.1.3 Calcium and Magnesium Ions.- 3.1.4 Chloride Ions.- 3.2 The Role of Active Ion Transport in Receptor Potential Generation.- 3.3 A Brief Conclusion.- 4 The First-order Code. Ionic Mechanisms of Signal Transformation in the Electrically Excitable Membrane of the Myelinated Fiber.- 4.1 The Main Postulates of the Membrane Ionic Theory. The Mathematical Hodgkin-Huxley Model.- 4.1.1 The Adaptational Behavior of the Ranvier Node Membrane Associated with a Constant Current Step.- 4.1.2 The Potassium Membrane Mechanism of Adaptation. The Role of Slow Channels.- 4.1.3 The Sodium Membrane Adaptational Mechanism. The Second-order Kinetics of Sodium Channel Conductance Inactivation.- 4.2 The Ionic Mechanisms of Numeric and Frequency Coding.- 4.2.1 The Potassium Mechanism of Numerical Coding. The Role of Makovsky Channels in Forming a Numerical Code.- 4.2.2 The Sodium Mechanism of Numeric Coding.- 4.2.3 The Ionic Mechanisms of Frequency Coding.- 4.3 Ionic Mechanisms of Nerve Impulse Generation in Sensory and Motor Fibers.- 4.4 A Brief Conclusion.- 5 The Effect of Biologically Active Substances upon Mechanoreceptors.- 5.1 The Effects of Catecholamines and the Sympathetic Nervous System on the Activity of Mechanoreceptors.- 5.1.1 The Influence of Catecholamines and the Sympathetic Nervous System on Muscle Spindle Activity.- 5.1.2 Morphological Data on the Sympathetic Innervation of the Muscle Spindles.- 5.1.3 The Influence of the Sympathetic Nervous System and Catecholamines upon the Activity of Cutaneous and Visceral Mechanoreceptors.- 5.1.4 Morphological Aspects of Sympathetic Innervation of Cutaneous and Visceral Mechanoreceptors.- 5.1.5 Mechanisms of Influence of the Sympathetic Nervous System and Catecholamines upon Mechanoreceptors.- 5.2 The Effect of Acetylcholine and Cholinolytics on Mechanoreceptors.- 5.2.1 The Effect of Acetylcholine on Muscle Spindles.- 5.2.2 The Effect of Acetylcholine on Cutaneous Receptors.- 5.2.3 Acetylcholine Effect on Visceral Receptors.- 5.2.4 The Effect of Cholinergic Antagonists.- 5.2.5 Histochemical Demonstration of Cholinesterase in Mechanoreceptors.- 5.2.6 The Mechanism of Acetylcholine Effect upon Mechanoreceptors.- 5.2.7 Does Acetylcholine Participate in the Primary Processes in Mechanoreceptors?.- 5.3 A Brief Conclusion.- 6 Summary.- References.