Medical Epigenetics

Hardcover | July 16, 2016

byTrygve Tollefsbol

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Medical Epigenetics is an inclusive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic disease that affect these systems, and modes of treating epigenetic-based disorders and diseases. This book provides stand-alone coverage of all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. It is useful not only to physicians, nurses, medical students, and many others directly involved with healthcare, but also investigators in life sciences, biotech companies, graduate students, and all others who are interested in more applied aspects of epigenetics. The expansion of the field of epigenetics has brought a wealth of information with respect to variations in phenotypes that are heritable. In addition, many advances have emerged that have shown epigenetic aberrations as central to a number of diseases and disorders that were previously thought to be manifested primarily through genetic factors. Along with the remarkable studies that have been made in our understanding of epigenetic-based diseases and disorders has come new information that allows treatments that target these many epigenetic aberrations. Medical Epigenetics brings all of this knowledge together to comprehensively review the state of medical epigenetics in one defining volume. The basic design of Medical Epigenetics is to lead the reader from the fundamental mechanisms of epigenetics as they apply to humans through approaches for treating epigenetic-based diseases. This book begins with the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics. Medical Epigenetics closes with a chapter on future prospects in medical epigenetics. This book is by far the most complete book in the area of applied epigenetics. Focuses on practical and applied aspects of medical epigenetics Includes peer-reviewed chapters with up-to-date coverage of emerging topics in medical epigenetics by leading experts Appeals to those interested in fundamental epigenetics and inheritance, as well as those with more clinical interests including practicing physicians and other health care professionals Covers the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics

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Medical Epigenetics is an inclusive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic disease that affect these systems, and modes of treating epigenetic-based disorders and diseases. This book provides stand-alone coverage of all human systems relevant to epigenetic maladies and all major aspects o...

Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the...

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Format:HardcoverDimensions:924 pages, 9.41 × 7.24 × 0.98 inPublished:July 16, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128032391

ISBN - 13:9780128032398

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Table of Contents

Section I: Overview

1. An Overview of Medical Epigenetics Trygve O. Tollefsbol

Section II: Basic Principles of Epigenetics

2. DNA Methylation: Basic Principles Cynthia A. Moylan and Susan K. Murphy

3. Histone-deacetylases as a therapeutic target in neurodegenerative diseases Farahnaz Sananbenesi and Andre Fischer

4. Basic principles of noncoding RNAs in epigenetics Ilaria Panzeri, Grazisa Rossetti and Massimiliano Pagani

Section III: General Medical Aspects of Epigenetics

5. Epidemiological Epigenetics in Medicine Alexander Vaiserman

6. Lifestyle and Preventive Medical Epigenetics Marcus V. Gomes

7. Environmental Medical Epigenetics: A Review of Epigenetically-induced Medical Risks Generated from Exposures in Our Air, Food, and Personal Products Rachel L. Miller

8. Behavioral Medical Epigenetics Olivia H. Cox and Richard S. Lee

9. Medical Epigenetics in Twins Joel C. Eissenberg

10. Epigenetic Biomarkers of Disease Philip D. Voyias, Abhilasha Patel and Ramesh P. Arasaradnam

11. Prognostic Epigenetics Anup Sharma, Eihab Abdelfatah, Maryam Al Eissa and Nita Ahuja

Section IV: Epigenetics of System Disorders

12. Immune System Disorders and Epigenetics Stuti Mehta and Kate L. Jeffrey

13. Pulmonary Diseases and Epigenetics Hong Peng, Dandan Zong, Zijing Zhou and Ping Chen

14. Cardiovascular Disorders and Epigenetics Charbel Abi Khalil

15. Epigenomics of Intestinal Disease Daniel Rory Kelly and Theresa Alenghat

16. Epigenetics of Skin Disorders Shuaihantian Luo and Qianjin Lu

17. Epigenetics in Bone and Joint Disorders N. Altorok, S. Nada, V. Nagaraja and Bashar Kahaleh

18. Epigenetics of Muscle Disorders Viviana Moresi, Nicoletta Marroncelli, Eva Pigna and Sergio Adamo

19. Epigenetics of Psychiatric Disorders Marija Kundakovic

20. Epigenetic Alterations in Endocrine-dependent Cancers: Implications of Endocrine Dysfunctions Genevieve Deblois and Mathieu Lupien

21. Reproductive Disease Epigenetics Rafael Oliva*

22. Epigenetics in Ocular Medicine Verity F. Oliver, Katherine A. van Bysterveldt and Shannath L. Merbs*

Section V: Multi-system Medical Epigenetics

23. Pediatric Diseases and Epigenetics Judith G. Hall*

24. Epigenetics of Infectious Diseases Kate L. Seib and Michael P. Jennings

25. Clinical Utility of Solid Tumor Epigenetics Soren Kristiansen and György Sölétormos

26. Epigenetic Control in Human Normal Follicular Thyroid Cells and in Thyroid Carcinoma Zeus Andrea Antonello and Carmelo Nucera

27. Epigenetics in Acute Myeloid Leukemia Cristina Giorgio, Carmela Dell Aversana and Lucia Altucci

28. Epigenetic Regulation in Cancer Metastasis Huan Wang, Yukun Zhang, Adam Kriska and Hong Chen

29. Epigenetics in Exercise Science and Sports Medicine Philipp Zimmer, Alexander Schenk and Wilhelm Bloch

30. Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease Rajesh C. Miranda, Nihal A. Salem, Annette S. Fincher, Amanda H. Mahnke and Sasha G. Burrowes

Section VI. Pharmacology of Epigenetics

31. Toxicology and Epigenetics Jian Tajbakhsh and Jatinder Singh

32. Pharmacoepigenomics Ramón Cacabelos and Clara Torrellas

Section VII: Therapeutic Epigenetics

33. Therapeutics and DNA Methylation Inhibitors Sheena Bhalla and Shyamala C. Navada

34. Histone Deacetylase Inhibitors in Medical Therapeutics Pusoon Chun

35. NAD+-dependent Deacetylases and Medical Therapy Ashok Kumar, Louisa Ben-Aderet, Jinan Elayan and Mona Dvir-Ginzberg*

36. Experimental Approaches Towards Histone Acetyltransferase Inhibitors as Therapeutics H. Wapenaar and Frank J. Dekker

37. Histone Methylation Modifiers in Medical Therapeutics Patrick Trojer 38. Therapeutics of Epigenetic-based RNA molecules Costas Koufaris* and Vicky Nicolaidou

39. Natural Epigenetic-modifying Molecules in Medical Therapy Avinash Kumar, Nasir A. Butt and Anait S. Levenson

40. Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic Paromita Raha

41. Epigenetics of Pain Management Beverley Greenwood-Van Meerveld, Dawn Prusator, Casey Ligon, Anthony C. Johnson and Rachel D. Moloney

42. Personalized Epigenetics Michael Bitzer and Nisar P. Malek

43. Epigenetics and Regenerative Medicine: Neural and Skeletal Muscle Perspectives Constantin Heil and Daniela Palacios

44. Stem Cell Epigenetics in Medical Therapy Baoli Cheng, Liqi Shu and Peng Jin

Section VIII: Medical Epigenetics: Future Prospects

45. Prospective Advances in Medical Epigenetics Junjie Xiao and Guoping Li