Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring by Brian J. NickoloffMelanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring by Brian J. Nickoloff

Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring

EditorBrian J. Nickoloff

Paperback | December 12, 2011

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In Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring, a broadly diverse group of researchers and clinicians offer not only reviews of the most important recent advances in melanoma oncology, tumor immunology, and pathology, but also state-of-the-art molecular techniques for probing its basic biology. These readily reproducible methods can be used to develop new diagnostic approaches, therapeutics, and status monitoring of patients suffering both early- and late-stage melanoma. With emphasis on the experimental details critical to experimental success, each method is described in step-by-step fahion by hands-on masters, often those who have developed hem in their own laboratories. Comprehensive and highly instructive, Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring offers both clinicians and basic scientists concerned with malignant melanoma both new clinical perspectives and the wide ranging experimental protocols essential for achieving more rapid breakthroughs in this near-epidemic disease.

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Title:Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and MonitoringFormat:PaperbackDimensions:382 pages, 9.02 × 5.98 × 0.07 inPublished:December 12, 2011Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617371343

ISBN - 13:9781617371349

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Table of Contents

Part I. BiologyThe Many Molecular Mysteries of MelanomaBrian J. NickoloffIsolation of Tumor Suppressor Genes in Melanoma by cDNA MicroarrayYan A. Su and Jeffrey M. TrentMolecular Characterization of Melanoma-Derived AntigensMarten Visser, Markwin P. Velders, Michael P. Rudolf, and W. Martin KastExperimental Induction of Human Atypical Melanocytic Lesions and Melanoma in Ultraviolet-Irradiated Human Skin Grafted to Immunodeficient MiceCarola Berking and Meenhard HerlynDissection of Immunosuppressive Effects of Ultraviolet RadiationStephen E. Ullrich and David A. SchmittAntisense Oligonucleotides as Research ToolsJennifer K. Taylor, Scott R. Cooper, and Nicholas M. DeanPart II. DiagnosisGenetic Testing in Familial Melanoma: Epidemiologic/Genetic Assessment of Risks and Role of CDKN2A AnalysisDavid Hogg, Ling Liu, and Norman LassamRole of Molecular Biology in Diagnostic Pathology of MelanomaAndrzej Slominski, Andrew Carlson, Jacobo Wortsman, and Martin C. MihmIdentification of Altered Gene Expression Associated with Pigmentary Lesions by Differential Display AnalysisI. Caroline Le Poole and Thomas L. BrownFluorescence In Situ Hybridization as a Tool in Molecular Diagnostics of MelanomaLionel J. CoignetPart III. TreatmentAntigen-Pulsed Dendritic Cell Approach to MelanomaFrank O. Nestle, Adrian Tun-Kyi, and Michel F. GillietGene Therapy in MelanomaGiorgio Parmiani, Flavio Arienti, Cecilia Melani, Filiberto Belli, Gianfrancesco Gallino, and Arabella MazzocchiUse of Gene Gun for Genetic Immunotherapy: In Vitro and In Vivo MethodsAlfred E. Chang, Keishi Tanigawa, Joel C. Turner, Edwin C. Chang, and Hua YuRole of Cytokines in Pathology of Melanoma and Use of Biologic Response Modifiers in MelanomaJoseph I. ClarkSurgical Techniques for Treatment of Primary Cutaneous MelanomaJune K. RobinsonPart IV. MonitoringUtility of Fine-Needle Aspiration Biopsy for Prospective Analysis of Patients Undergoing Therapy for Metastatic MelanomaAdam I. RikerA Molecular Technique Useful in the Detection of Occult Metastases in Patients with Melanoma: RT-PCR Analysis of Sentinel Lymph Nodes and Peripheral BloodJames S. Goydos and Douglas S. ReintgenImmunoscope Analysis of T-Lymphocytes Infiltrating Melanocytic TumorsPhilippe Musette, Jos Even, Louis Dubertret, Philippe Kourilsky, and Gabriel GachelinT-Cell Receptor Clonotype Mapping Using Denaturing Gradient Gel Electrophoresis: Analysis of Clonal T-Cell, Responses in MelanomaPer thor Straten, Jürgen C. Becker, Jesper Zeuthen, and Per GuldbergMethods for Use of Peptide-MHC Tetramers in Tumor ImmunologyCassian Yee and Peter P. Lee

Editorial Reviews

Foreword by Leroy HoodFinalist for the Book of the Year Award, Health Science Books, 2001.-Doody's Health Sciences Book Review Journal "The topics covered are broad and, appropriately for a book concerned with techniques and protocols, the text is very detailed in places. There are chapters on analysis of gene expression, isolation of tumor suppression genes in melanoma, characterization of melanoma antigens, differential display analysis, and techniques that aim to reflect the extent of disease based on analyses of lymph node material and blood. All of these topics are important for those who want to be at the margin of advances in research. . .anybody interested in melanoma research or therapy should ensure the book is in their university or departmental library."-Journal of Investigative Dermatology"This book focuses on the most important molecular advances in melanoma epidemiology, carcinogenesis, diagnosis, pathology, and treatment. It uniquely provides state-of-the-art molecular techniques to allow novel and reproducible investigation by melanoma researchers worldwide. . .The book is directed towards clinicians and diagnosticians (dermatologists, pathologists, surgeons, and oncologists) with a dedicated, academic melanoma practice and to basic science investigators studying the molecular biology, tumor immunology, pathology, diagnosis, and treatment of melanoma. The author has assembled a team of renowned molecular biologists and melanoma experts to contribute to the text and is a credible authority on the subject matter. . .Four main areas addressing melanoma biology, diagnosis, treatment, and monitoring from the molecular level to the clinical level comprise the book. It focuses on modern genomics and specific molecular techniques such as cDNA microarray, differential display analysis, in situ hybridization, gene therapy, RT-PCR analysis, peptide-MHC tetramer assay, and gel electrophoresis, and provides state-of-the art melanoma research. Most importantly, it provides specific scientific protocols to ensure reproducibility in other laboratories. . .The book is far-reaching in its goal of enhancing the investigative efforts of melanoma researchers worldwide to promote chances of clinical breakthroughs in the field of melanoma."-Doody's Health Sciences Book Review Journal"Comprehensive and highly instructive, this volume offers clinicians and basic scientists concerned with malignant melanoma both rich new clinical perspectives and the wide ranging experimental protocols essential for achieving more rapid breakthroughs in this near-epidemic disease." - Anticancer Research"...anybody interested in melanoma research or therapy should ensure the book is in their university and departmental library." -Journal of Investigative Dermatology"Comprehensive and highly instructive, Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring offers clinicians and basic scientists concerned with malignant melanoma both rich new clinical perspectives and the wide-ranging experimental protocols essential for achieving more rapid breakthroughs in this near-epidemic disease." -Tumori"The book represents an outstanding work, which should not be missed in all laboratories dealing with melanoma as well as in all departments where melanoma patients are diagnosed and treated." -Neoplasma"This book on the biology, immunology, pathology and microbiology of melanoma deserves a place in the library of all units with a specific interest in melanoma research and management...recommended for anybody working in the field of microbiology. It gives a good overview of the entire field of melanoma microbiology and enables those with a specialised interest in a specific area of microbiology to review and utilise the work of other researchers in this importatn and rapidly developing field." -Cancer Forum"Comprehensive and highly instructive, Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring offers clinicians and basic scientists concerned with malignant melanoma both rich new clinical perspectives and the wide ranging experimental protocols essential for achieving more rapid breakthroughs in this near-epidemic disease." -Tumori