Membrane Dynamics and Domains: Subcellular Biochemistry

Hardcover | July 2, 2004

EditorPeter J. Quinn

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This volume assembles contemporary evidence of domain formation in membranes gathered by leading researchers in fields ranging from membrane biophysics to cell biology. Questions relating to how non-random membrane arrangements are defined, detected and monitored to characterise their dynamic behaviour are addressed. The components associated with membrane rafts are examined and the different mechanisms employed to create membrane microdomains are considered. Evidence relating to the regulation of membrane microdomain formation in the context of membrane biogenesis and homeostasis is discussed. The role of membrane domain formation in the generation and transmission of signals transduced via membranes to evoke a variety of physiological responses is examined and examples of where membrane domain structures are involved in infection and disease states are provided.

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This volume assembles contemporary evidence of domain formation in membranes gathered by leading researchers in fields ranging from membrane biophysics to cell biology. Questions relating to how non-random membrane arrangements are defined, detected and monitored to characterise their dynamic behaviour are addressed. The components ass...

Format:HardcoverDimensions:515 pages, 9.25 × 6.1 × 0.04 inPublished:July 2, 2004Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0306484250

ISBN - 13:9780306484254

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Table of Contents

1: Membrane Domain Structure. Membrane Receptor Mapping: Membrane Topography of FcepsilonRI Signalling; J.M. Oliver, J.R. Pfeiffer, Z. Surviladze, S.L Steinberg, K. Leiderman, M.L. Sanders, C. Wofsy, Jun Zhang, Hong You Fan, N. Andrews, S. Bunge, T.J. Boyle, P. Kotula, B.S. Wilson. Rafts, Little Caves and Large Potholes: How Lipid Structure Interacts With Membrane Proteins to Create Functionally Diverse Membrane Environments; R. Morris, H. Cox, E. Mombelli, P.J. Quinn. 2: Membrane Domain Composition. Lipid Raft Proteins and their Identification in T Lymphocytes; B. Wollscheid, R. Aebersold, J.D. Watts. Lipid Composition of Membrane Domains; K.S. Koumanov, C. Wolf, P.J. Quinn. 3: Creation of Membrane Microdomains. Sphingomyelin and Cholesterol: From Membrane biophysics and rafts to potential medical applications; Y. Barenholz. Membrane Targeting of Signal Transduction Proteins; M.D. Resh. Role of the membrane skeleton in creation of microdomains; K. Ritchie, A. Kusumi. Membrane/Cytoskeleton Communication; K.F. Meiri. 4: Regulation of Domain Formation. GPI-anchored Protein Cleavage in the Regulation of Transmembrane Signals; F.J. Sharom, G. Radeva. Membrane Lipid Homeostasis; C. Wolf, P.J. Quinn. Phospholipid Metabolism in Lung Surfactant; R. Veldhuizen, F. Possmayer. 5: Signal Transduction Processes. Membrane Targeting in Secretion; M. Schrader. 6: Domain Dynamics in Disease. Oxidative Stress, caveolae and caveolin-1; M.-O. Parat, P.L. Fox. The role of lipid microdomains in virus biology; D.P. Nayak, E. K.-W. Hui.