Mental Retardation and Developmental Delay: Genetic and Epigenetic Factors by Moyra SmithMental Retardation and Developmental Delay: Genetic and Epigenetic Factors by Moyra Smith

Mental Retardation and Developmental Delay: Genetic and Epigenetic Factors

byMoyra Smith

Hardcover | September 11, 2006

Pricing and Purchase Info


Earn 325 plum® points

Prices and offers may vary in store


Ships within 1-3 weeks

Ships free on orders over $25

Not available in stores


Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulationof gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential toneurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of boththe environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well asmultifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells.
Moyra Smith is at University of California, Irvine (Emeritus).
Title:Mental Retardation and Developmental Delay: Genetic and Epigenetic FactorsFormat:HardcoverDimensions:344 pages, 6.3 × 9.29 × 0.79 inPublished:September 11, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195174321

ISBN - 13:9780195174328


Table of Contents

Introduction1. Science, Society, and Mental Retardation, A History2. Neurogenesis, Neuronal Migration, Maturation, and Function: Insights into Learning and Memory3. Structural Brain Anomalies and Neural Tube Defects4. Mental Retardation Associated with Dysmorphology, Growth Retardation, or Overgrowth5. Mental Retardation Associated with Other Neurological Defects6. Mental Retardation that Develops After a Period of Norma Cognition7. Nonsyndromic Mental Retardation, Autism, and Language Deficits8. Genomics, Functional Genomics, and Epigenetics: Relevance to Mental Retardation9. Establishing a Diagnosis and Determining Etiology in Developmental Delay and Mental Retardation10. Epilogue: The Value of Genetic Diagnosis-Applying Knowledge About Etiology to Prevention and TreatmentReferencesIndex

Editorial Reviews

"This book is a little gem...The remit is extensive and the book is compact. It will therefore be a useful summary of current understanding to be used as a reference and would be particularly helpful for medical undergraduates invovled in a vertically constructed curriculum or forpediatricians, whether in training or maintaining their CPD. It is not just a book for someone who wants to know the answer, but for someone who wants to know why the answer is as it is and rejoices in the explanation."--Archives of Disease in Childhood