Mental Retardation and Developmental Delay: Genetic and Epigenetic Factors

Hardcover | September 11, 2006

byMoyra Smith

not yet rated|write a review
Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulationof gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential toneurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of boththe environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well asmultifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells.

Pricing and Purchase Info

$64.95

Ships within 1-3 weeks
Ships free on orders over $25

From the Publisher

Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulationof gene expression, epigenetics, and functi...

Moyra Smith is at University of California, Irvine (Emeritus).

other books by Moyra Smith

Molecular Insights into Development in Humans: Studies in Normal Development and Birth Defects
Molecular Insights into Development in Humans: Studies ...

Kobo ebook|Nov 20 2014

$58.69 online$76.12list price(save 22%)
Investigating the Human Genome: Insights into Human Variation and Disease Susceptibility
Investigating the Human Genome: Insights into Human Var...

Kobo ebook|Jun 8 2011

$50.59 online$65.60list price(save 22%)
see all books by Moyra Smith
Format:HardcoverDimensions:344 pages, 6.3 × 9.29 × 0.79 inPublished:September 11, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195174321

ISBN - 13:9780195174328

Look for similar items by category:

Customer Reviews of Mental Retardation and Developmental Delay: Genetic and Epigenetic Factors

Reviews

Extra Content

Table of Contents

Introduction1. Science, Society, and Mental Retardation, A History2. Neurogenesis, Neuronal Migration, Maturation, and Function: Insights into Learning and Memory3. Structural Brain Anomalies and Neural Tube Defects4. Mental Retardation Associated with Dysmorphology, Growth Retardation, or Overgrowth5. Mental Retardation Associated with Other Neurological Defects6. Mental Retardation that Develops After a Period of Norma Cognition7. Nonsyndromic Mental Retardation, Autism, and Language Deficits8. Genomics, Functional Genomics, and Epigenetics: Relevance to Mental Retardation9. Establishing a Diagnosis and Determining Etiology in Developmental Delay and Mental Retardation10. Epilogue: The Value of Genetic Diagnosis-Applying Knowledge About Etiology to Prevention and TreatmentReferencesIndex

Editorial Reviews

"This book is a little gem...The remit is extensive and the book is compact. It will therefore be a useful summary of current understanding to be used as a reference and would be particularly helpful for medical undergraduates invovled in a vertically constructed curriculum or forpediatricians, whether in training or maintaining their CPD. It is not just a book for someone who wants to know the answer, but for someone who wants to know why the answer is as it is and rejoices in the explanation."--Archives of Disease in Childhood