Metabolic Engineering: Principles and Methodologies by George StephanopoulosMetabolic Engineering: Principles and Methodologies by George Stephanopoulos

Metabolic Engineering: Principles and Methodologies

byGeorge Stephanopoulos, Aristos A. Aristidou, Jens Nielsen

Hardcover | October 2, 1998

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Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes.

Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems.



  • Demonstrates metabolic engineering in action with numerous examples of pathway modification
  • Includes methods for identifying key enzymes in metabolic networks
  • Contains a comprehensive review of metabolic biochemistry
  • Discusses metabolic regulation at the gene, enzyme, operon, and cell levels
  • Explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways
  • Minimizes mathematical complexity
  • Links to a Web page to communicate updates of the software code and homework problems
Gregory Stephanopoulos is a Professor of Chemical Engineering at MIT. He received his B.S. from the National Technical University of Athens, his M.S. from the University of Florida and his Ph.D. from the University of Minnesota, all in Chemical Engineering. Upon graduation, he joined the Chemical Engineering Faculty of the California I...
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Title:Metabolic Engineering: Principles and MethodologiesFormat:HardcoverDimensions:725 pages, 9 × 6 × 0.98 inPublished:October 2, 1998Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0126662606

ISBN - 13:9780126662603

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Table of Contents

The Essence of Metabolic Engineering
Review of Cellular Metabolism
Comprehensive Models for Cellular Reactions
Material Balances and Data Consistency
Regulation of Metabolic Pathways
Examples of Pathway Manipulations: Metabolic Engineering in Practice
Metabolic Pathway Synthesis. Metabolic Flux Analysis
Methods for the Experimental Determination of Metabolic Fluxes by Isotope Labeling
Applications of Metabolic Flux Analysis
Metabolic Control Analysis
Analysis of Structure of Metabolic Networks
Flux Analysis of Metabolic Networks
Thermodynamics of Cellular Processes