Metabolic Engineering: Principles and Methodologies

Hardcover | October 2, 1998

byGeorge Stephanopoulos, Aristos A. Aristidou, Jens Nielsen

not yet rated|write a review
Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes.Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems. Key Features* Demonstrates metabolic engineering in action with numerous examples of pathway modification * Includes methods for identifying key enzymes in metabolic networks * Contains a comprehensive review of metabolic biochemistry* Discusses metabolic regulation at the gene, enzyme, operon, and cell levels* Explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways* Minimizes mathematical complexity * Links to a Web page to communicate updates of the software code and homework problems

Pricing and Purchase Info

$241.79 online
$314.95 list price (save 23%)
In stock online
Ships free on orders over $25

From the Publisher

Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification t...

From the Jacket

Metabolic engineering is an emerging, interdisciplinary field with applications to the production of chemicals, fuels, materials, and pharmaceuticals. The field's novelty lies in the integration of the techniques of molecular biology with the tools of mathematical analysis, to help elucidate metabolic flux control and rational selectio...

Gregory Stephanopoulos is a Professor of Chemical Engineering at MIT. He received his B.S. from the National Technical University of Athens, his M.S. from the University of Florida and his Ph.D. from the University of Minnesota, all in Chemical Engineering. Upon graduation, he joined the Chemical Engineering Faculty of the California I...

other books by George Stephanopoulos

Process Modelling and Model Analysis
Process Modelling and Model Analysis

Kobo ebook|May 23 2001

$117.89 online$153.00list price(save 22%)
see all books by George Stephanopoulos
Format:HardcoverDimensions:725 pages, 9 × 6 × 0.98 inPublished:October 2, 1998Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0126662606

ISBN - 13:9780126662603

Look for similar items by category:

Customer Reviews of Metabolic Engineering: Principles and Methodologies

Reviews

Extra Content

Table of Contents

The Essence of Metabolic Engineering. Review of Cellular Metabolism. Comprehensive Models for Cellular Reactions. Material Balances and Data Consistency. Regulation of Metabolic Pathways. Examples of Pathway Manipulations: Metabolic Engineering in Practice. Metabolic Pathway Synthesis. Metabolic Flux Analysis. Methods for the Experimental Determination of Metabolic Fluxes by Isotope Labeling. Applications of Metabolic Flux Analysis. Metabolic Control Analysis. Analysis of Structure of Metabolic Networks. Flux Analysis of Metabolic Networks. Thermodynamics of Cellular Processes. Glossary. Subject Index.