Metals and Oxidative Damage in Neurological Disorders

Hardcover | September 30, 1997

EditorJames R. Connor, James R. Connor

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This volume brings together scientists and clinicians from diverse disciplines for discussions of oxidative injury in the nervous system. Areas of examination include: a review of metals and their role in oxidative injury, with special attention paid to iron the mechanisms by which the brain protects itself from oxidative harm the clinical diseases in which oxidative injury is known to contribute to the pathogenic process antioxidant therapeutic strategies in neurological disorders, and a proposed common pathway for oxidative injury in the brain.

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This volume brings together scientists and clinicians from diverse disciplines for discussions of oxidative injury in the nervous system. Areas of examination include: a review of metals and their role in oxidative injury, with special attention paid to iron the mechanisms by which the brain protects itself from oxidative harm...

Format:HardcoverDimensions:396 pages, 10 × 7.01 × 0.27 inPublished:September 30, 1997Publisher:Springer US

The following ISBNs are associated with this title:

ISBN - 10:030645534X

ISBN - 13:9780306455346

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Table of Contents

Evidence for Iron Mismanagement in the Brain in Neurological Disorders; J.R. Connor. Iron and Neurotransmitter Function in the Brain; Y. Glinka, et al. Magnetic Resonance Imaging of Brain Iron; G. Bartzokis. Neurochemical Roles of Copper as Antioxidant or Prooxidant; J.R. Prohaska. Manganese Neurotoxicity and Oxidative Damage; M. Aschner. The Role of Zinc in Brain and Nerve Functions; A.S. Prasad. Delivery of Metals to Brain and the Role of the Blood-Brain Barrier; Q.R. Smith, et al. Ferritin: Intracellular Regulator of Metal Availability; J.G. Joshi. Ascorbate: An Antioxidant Neuroprotectant and Extracellular Neuromodulator; G.V. Rebec. Vitamin E: Neurochemical Aspects and Relevance to Nervous System Disorders; G.T. Vatassery. Nitric Oxide and Oxidative Damage in the CNS; D.A. Dawson. Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury: Directions for Therapeutic Intervention; C. Palmer. The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer's Disease; L.A. Shinobu, M.F. Beal. Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase; D.R. Borchelt, et al. 3 Additional Chapters. Appendix. Index.