Metchnikoff and the Origins of Immunology: From Metaphor to Theory

Hardcover | March 1, 1995

byAlfred I. Tauber, Leon Chernyak

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This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells. His programdeveloped from comparative embryological studies that sought to establish genealogical relations between species at the dawn of the Darwinian revolution. In this scientific biography, Tauber and Chernyak explore ore Metchnikoff's development as an embryologist, showing how it prepared him topropose his theory of host-pathogen interaction. They discuss the profound impact of Darwin's theory of evolution on Metchnikoff's progress, and the influence of 19th century debates on vitalism, teleology, and mechanism. As a case study of scientific discovery, this work offers lucid insight intothe process of creative science and its dependence on cultural and philosophic sources. Immunologists and historians of science and medicine will find it an absorbing and accessible account of a remarkable individual.

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From Our Editors

This fascinating scientific biography is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory phagocytic cells actively defend the host body against pathogens and disease. It was the first theory of active immunity, but only a segment of an en...

From the Publisher

This fascinating intellectual history is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory that phagocytic cells actively defend the host body against pathogens and diseased cells. His programdeveloped from comparative embryological studi...

From the Jacket

This fascinating scientific biography is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory phagocytic cells actively defend the host body against pathogens and disease. It was the first theory of active immunity, but only a segment of an en...

Alfred I. Tauber and Leon Chernyak are both of Boston University School of Medicine.

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Format:HardcoverDimensions:280 pages, 9.49 × 6.46 × 0.87 inPublished:March 1, 1995Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:019506447X

ISBN - 13:9780195064476

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Table of Contents

1. Introduction2. Metchnikoff's Early Embryology3. Metchnikoff's Embryological Studies after 18724. The Problem of Evolution in Metchnikoff's Works5. Metchnikoff's Emerging Concept of Inflammation6. The Phagocytosis Theory and Its Reception7. The Phagocyte Eclipsed8. Epilogue: From Metaphor to Theory

From Our Editors

This fascinating scientific biography is the first critical study of the work of Elie Metchnikoff, the founding father of modern immunology. Metchnikoff authored and championed the theory phagocytic cells actively defend the host body against pathogens and disease. It was the first theory of active immunity, but only a segment of an encompassing theory of self hood achieved through self-defining, dynamic processes.

Editorial Reviews

"A scholarly and richly documented study." --Elisha Atkins, Journal of the History of Medicine