Methods for the Discovery and Characterization of G Protein-Coupled Receptors by Craig W. StevensMethods for the Discovery and Characterization of G Protein-Coupled Receptors by Craig W. Stevens

Methods for the Discovery and Characterization of G Protein-Coupled Receptors

EditorCraig W. Stevens

Hardcover | July 15, 2011

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The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies.  In Methods for the Discovery and Characterization of G Protein-Coupled Receptors, experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader's particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors.  Chapters also feature an important section called "Future Directions" which gives the reader an insight into advances soon to be realized in each area. Written for the popular Neuromethods series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods for the Discovery and Characterization of G Protein-Coupled Receptors serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.
Title:Methods for the Discovery and Characterization of G Protein-Coupled ReceptorsFormat:HardcoverDimensions:441 pagesPublished:July 15, 2011Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617791784

ISBN - 13:9781617791789

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Table of Contents

Part I: The G Protein-Coupled Receptor in the Genome 1. In Silico Identification of Novel G Protein-Coupled Receptors            Matthew N. Davies, David E. Gloriam, and Darren R. Flower 2. Alternative Pre-mRNA Splicing of G Protein-Coupled Receptors            Ying-Xian Pan, Steven Grinnell, and Gavril W. Pasternak 3. Detecting Polymorphisms in G Protein-Coupled Receptor Genes            Dmitri Proudnikov, Vadim Yuferov, and Mary Jeanne Kreek 4. Regulation of the Transcription of G Protein-Coupled Receptor Genes            Cheol Kyu Hwang, Ping-Yee Law, Li-Na Wei, and Horace H. Loh 5. Deciphering the Evolution of G Protein-Coupled Receptors in Vertebrates            Craig W. Stevens Part II: The Trafficking of G Protein-Coupled Receptors 6. A New Approach to Visualize Endogenously Expressed G Protein-Coupled Receptors in Tissues and Living Cells            Brigitte L Kieffer and Grégory Scherrer 7. Post-Translational Regulation of G Protein-Coupled Receptors            Yu Qiu and Ping-Yee Law 8. Discovering G Protein-Coupled Receptor Motifs Mediating Export from the Endoplasmic Reticulum            Chunmin Dong and Guangyu Wu 9. Identifying G Protein-Coupled Receptor Escorts, Chaperones, and Intracellular Tethers Regulating Receptor Density at the Cell Surface            Stefano Marullo, Liliana Pardo Lopez, and Lamia Achour 10. A Novel Method for Determining the Kinetics of G Protein-Coupled Receptor Plasma Membrane Expression            Gregory W. Sawyer Part III: The G Protein-Coupled Receptor on the Membrane 11. Characterizing the Pharmacology of G Protein-Coupled Receptors in Transfected Cell Lines            Kathryn A. Seely and Paul L. Prather 12. Novel Assay Technologies for the Discovery of G Protein-Coupled Receptor Drugs            Elisa Alvarez-Curto, Richard J. Ward, and Graeme Milligan 13. Discovering Cell-Type-Specific Patterns of G Protein-Coupled Receptor Phosphorylation            Kok Choi Kong, Andrew B. Tobin, and Adrian J. Butcher 14. Quantifying Allosteric Modulation of G Protein-Coupled Receptors            Frederick J. Ehlert and Hinako Suga 15. Experimental Designs for the Study of Receptor-Receptor Interactions            Dennis Paul Part IV: The Regulation of G Protein-Coupled Receptors 16. Elucidating Agonist-Selective Mechanisms of G Protein-Coupled Receptor Desensitization            Chris P. Bailey and Eamonn Kelly 17. Detecting the Role of Arrestins in G-Protein Coupled Receptor Regulation            Laura M. Bohn and Patricia H. McDonald 18. Characterizing Molecular Mobility and Membrane Interactions of G Protein-Coupled Receptors            Vladana Vukojevic, Yu Ming, and Lars Terenius 19. Using RNA Interference to Downregulate G Protein-Coupled Receptors            Philippe Sarret, Louis Doré-Savard, Pascal Tétreault, Valérie Bégin-Lavallée, Marc-André Dansereau, and Nicolas Beaudet 20. Upregulating G Protein-Coupled Receptors with Receptor Antagonists            Ellen M. Unterwald