Methods in Neuronal Modeling: From Ions to Networks

Paperback | January 1, 2003

EditorChristof Koch, Idan Segev

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Much research focuses on the question of how information is processed in nervous systems, from the level of individual ionic channels to large-scale neuronal networks, and from "simple" animals such as sea slugs and flies to cats and primates. New interdisciplinary methodologies combine a bottom-up experimental methodology with the more top-down-driven computational and modeling approach. This book serves as a handbook of computational methods and techniques for modeling the functional properties of single and groups of nerve cells.The contributors highlight several key trends: (1) the tightening link between analytical/numerical models and the associated experimental data, (2) the broadening of modeling methods, at both the subcellular level and the level of large neuronal networks that incorporate real biophysical properties of neurons as well as the statistical properties of spike trains, and (3) the organization of the data gained by physical emulation of the nervous system components through the use of very large scale circuit integration (VLSI) technology.The field of neuroscience has grown dramatically since the first edition of this book was published nine years ago. Half of the chapters of the second edition are completely new; the remaining ones have all been thoroughly revised. Many chapters provide an opportunity for interactive tutorials and simulation programs. They can be accessed via Christof Koch's Website.Contributors : Larry F. Abbott, Paul R. Adams, Hagai Agmon-Snir, James M. Bower, Robert E. Burke, Erik de Schutter, Alain Destexhe, Rodney Douglas, Bard Ermentrout, Fabrizio Gabbiani, David Hansel, Michael Hines, Christof Koch, Misha Mahowald, Zachary F. Mainen, Eve Marder, Michael V. Mascagni, Alexander D. Protopapas, Wilfrid Rall, John Rinzel, Idan Segev, Terrence J. Sejnowski, Shihab Shamma, Arthur S. Sherman, Paul Smolen, Haim Sompolinsky, Michael Vanier, Walter M. Yamada.

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Much research focuses on the question of how information is processed in nervous systems, from the level of individual ionic channels to large-scale neuronal networks, and from "simple" animals such as sea slugs and flies to cats and primates. New interdisciplinary methodologies combine a bottom-up experimental methodology with the mor...

Christof Koch is Professor of Biology and of Engineering at the California Institute of Technology and Chief Scientific Officer of the Allen Institute for Brain Science in Seattle. He is the author of The Quest for Consciousness and other books.

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Format:PaperbackDimensions:687 pages, 9.1 × 7.2 × 1.5 inPublished:January 1, 2003Publisher:The MIT PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0262517132

ISBN - 13:9780262517133

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"An admirable concentration of expertise on state-of-the-art neuronalmodeling techniques—a must on the bookshelf of computationalneuroscientists and theoretical neurobiologists." Wolf Singer , M.D., Ph.D., Max-Planck-Institute for Brain Research