Microsatellites: Evolution and Applications

Paperback | June 1, 1999

EditorDavid B. Goldstein, Christian Schlotterer

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Microsatellites are short stretches of repeated DNA, found in most genomes, that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for most applications, including genetic mapping and studies of theevolutionary connections between species and populations. This book brings together an international group of scientists currently working in microsatellites. Their contributions provide a detailed description of microsatellite biology, focusing on their mutation properties, generation, decay, andpossible functional roles. They introduce the theoretical models that underpin the most popular methods for analysing the information that microsatellites can yield, including methods for estimating coalescent times, population divergences, and migration. Finally, the book describes the various waysin which the potential of microsatellites is being harnessed in a range of applications including medical genetics, forensics, genetic mapping, the analysis of human evolution, and conservation genetics.

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Microsatellites are short stretches of repeated DNA, found in most genomes, that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for most applications, including genetic mapping and studies of theevolutionary connections between species and population...

David B Goldstein, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS david.goldstein@zoo.ox.ac.uk Christian Schlotterer, Institut fur Tierzucht und Genetik, Veterinarmedizinische Universitat Wien, Vienna, Austria christian.schloetterer@vu-wien.ac.at

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Format:PaperbackPublished:June 1, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198504071

ISBN - 13:9780198504078

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Table of Contents

1. Hancock: Microsatellites and other simple sequences2. Kashi and Soller: Functional roles of microsatellites and minisatellites3. Armour et al: Microsatellites and mutation processes in tandemly repetitive DNA4. Eisen: Mechanistic basis for microsatellite instability5. Estoup and Cornuet: Microsatellite evolution : inferences from population data6. Amos: A comparative approach to the study of microsatellite evolution7. Rubinsztein: Trinucleotide expansion mutations cause diseases which do not conform to Mendelian expectations8. Feldman: Mutation and migration in models of microsatellite evolution9. Donnelly: The coalescent and microsatellite variability10. Reich and Goldstein: Estimating the age of mutations using variation of linked markers11. Chakraborty and Kimmel: Statistics of microsatellite loci : Estimation of mutation rate and pattern of population expansion12. Pemberton et al: Using microsatellites to measure the fitness consequences of inbreeding and outbreeding13. Beaumont and Bruford: Microsatellites in conservation genetics14. Linares: Microsatellites and the reconstruction of the history of human populations15. Balding: Forensic applications of microsatellite markers16. Stephens et al: Tracking linkage disequilibrium in advanced population with microsatellite loci17. Carrington et al: Microsatellite markers in complex disease : mapping disease - associated regions within the human MHC18. Schlotterer and Wiehe: Microsatellites : a neutral marker to infer selective sweeps19. Karafet et al: Y chromosome microsatellite haplotypes and the history of Samoyed-speaking populations in N-W Siberia20. Shibata: MS analysis of human tumours

Editorial Reviews

'...It is the most comprehensive volume on microsatellities and has contributions from many excellent researchers' TREE