Midkine: From Embryogenesis to Pathogenesis and Therapy by Mine ErgüvenMidkine: From Embryogenesis to Pathogenesis and Therapy by Mine Ergüven

Midkine: From Embryogenesis to Pathogenesis and Therapy

EditorMine Ergüven, Takashi Muramatsu, Ayhan Bilir

Hardcover | May 23, 2012

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Carl Edward Sagan's (1934-1996) one of the famous quotation was "Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people." From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named "Midkine" This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.
Title:Midkine: From Embryogenesis to Pathogenesis and TherapyFormat:HardcoverDimensions:328 pagesPublished:May 23, 2012Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9400742339

ISBN - 13:9789400742338

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Table of Contents

PART I:  GENERAL ASPECTS OF MIDKINECHAPTER  1         General information on midkineCHAPTER  2         The role of midkine in neural development and patterningCHAPTER  3         Midkine-  A player in innate immunityCHAPTER  4         Midkine/p63 axis in regulation of epithelial-mesenchymal transitionCHAPTER  5        Immunochemical methods for the detection of midkine in samples of human originCHAPTER  6        Circulating midkine in malignant, inflammatory, and infectious diseases: a systematic review PART II: MIDKINE AND INFLAMMATIONCHAPTER  7         Midkine in inflammation and inflammatory diseasesCHAPTER  8        Rheumatoid arthritis and midkine PART III: MIDKINE AND THE CARDIOVASCULAR SYSTEMCHAPTER  9         Midkine and heart failureCHAPTER  10       Vascular restenosis and midkineCHAPTER  11       The potential of MK through the renin-angiotensin system PART IV: MIDKINE AND THE NERVOUS SYSTEM CHAPTER  12       Midkine and Multiple sclerosisCHAPTER  13       MK gene transfer in brain infarctionCHAPTER  14       Midkine in psychiatric and neurodegenerative diseases    PART V: MIDKINE  AND THE UROGENITAL SYSTEM, REPRODUCTION AND AGINGCHAPTER  15       Role of midkine in nephrogenesis and kidney Disease CHAPTER  16      Midkine, a factor promoting cytoplasmic maturation of oocytesCHAPTER 17        Endometriosis may be promoted by midkine: possible involvement of ovarian folliclesCHAPTER 18        Stem cells and midkineCHAPTER 19        Midkine in skeletal physiologyPART VI MIDKINE AND CANCERCHAPTER 20        Midkine  and chemotherapy resistance in cancersCHAPTER 21       A  gene medicine with the midkine transcriptional regulation as new cancer therapeuticsCHAPTER 22       Midkine  as a tumor shared antigenCHAPTER 23       Midkine in prostate cancerCHAPTER 24       Midkine is a potential therapeutic target of hepatocellular carcinomaCHAPTER 25       Midkine in glioblastoma with the modulator role switching autophagy to cell death or cell survivalCHAPTER 26      Colon cancer and midkineCHAPTER 27       Osteosarcoma and midkineIndex.