Mild Cognitive Impairment: Aging to Alzheimers Disease

Hardcover | January 15, 2003

EditorRonald C. Petersen, The Mayo Foundation

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What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinicalinvestigators have identified a transitional condition between normal aging and and very early Alzheimer's disease that they have called mild cognitive impairment, or MCI. This term typically refers to memory impairment beyond what one would expect in individuals of a given age whose otherabilities to function in daily life are well preserved. Persons who meet the criteria for mild cognitive impairment have an increased risk of progressing to Alzheimer's disease in the near future. Though many questions about this condition and its underlying neuropathology remain open, fullclinical trials are currently underway worldwide aimed at preventing the progression from MCI to Alzheimer's disease. This book addresses the spectrum of issues involved in mild cognitive impairment, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology,biological markers, diagnostic approaches, and treatment. It is intended for clinicians, researchers, and students interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, and neuropsychologists.

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What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinicalinvestigators have identified a transitional conditi...

Ronald C. Peterson is at Mayo Clinic and Medical School.

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Format:HardcoverDimensions:288 pages, 6.3 × 9.41 × 0.98 inPublished:January 15, 2003Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195123425

ISBN - 13:9780195123425

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Table of Contents

1. Introduction, Ronald C. Petersen2. Clinical Features, Ronald C. Petersen, John C. Morris3. Neuropsychiatric Symptoms, Jeffrey L. Cummings4. Normative Neuropsychology in Aging and Mild Cognitive Impairment, Glenn E. Smith, Robert J. Ivnik5. Optimizing Cognitive Test Norms for Detecting Mild Cognitive Impairment, Martin Sliwinski, Richard Lipton, Herman Buschke, Christina Wasylyshyn6. Magnetic Resonance Imaging, Clifford R. Jack, Jr.7. Functional Imaging, Marilyn S. Albert, Keith A. Johnson8. Spectrum of Pathology from Normal Function to Mild Cognitive Impairment, Heiko Braak, Eva Braak9. Role of Entorhinal Cortext and Superior Temporal Sulcus, Bradley T. Hyman, Teresa Gomez-Isla10. Biological Markers, Neill R. Graff-Radford, Steven G. Younkin11. Clinical Evaluation, Ronald C. Petersen12. Treatment of Mild Cognitive Impairment and Prevention of Alzheimer's Disease, David S. Knopman

Editorial Reviews

"...this book offers a useful summary of the relevant research across topics and issues pertaining to the concept of MCI."--Applied Neuropsychology