Mind, Brain, And Schizophrenia

Hardcover | October 12, 2005

byPeter Williamson

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Over the last two decades, molecular genetics and brain imaging have guided efforts to find the causes of schizophrenia. It is becoming increasingly clear that many genes are involved in schizophrenia and that they interact with other factors in very complex ways, which have not yet beenelucidated. Neuroimaging techniques have allowed scientists and physicians to examine brain structure, function, and chemistry in living patients with schizophrenia but results so far have been disappointing. No two patients seem to share exactly the same combination of clinical symptoms orphysical findings. Yet all have the syndrome recognized as schizophrenia. The author of this accessible, well-written book argues that it is time to set aside the search for a single cause of schizophrenia and focus on the disease's final common pathway. He highlights clues from a wide rangeof research, including neurotransmitter, psychophysiological, and brain imaging studies. He then describes possibilities for the final common pathway at an understandable level in the context of what is already known about schizophrenia. While there are no preferred models of schizophrenia, apattern is emerging which implicates those structures in the brain known to be important in integrating perception, cognition, and affect. A better understanding of these processes will be critical for developing more effective treatments. This book will help advance that effort. It will be ofgreat value to psychiatrists, psychologists, neurologists, neuroimagers, and basic scientists working in the field of schizophrenia research, and to their students and trainees. It will also be of interest to clinicians and scientists concerned with other neuropsychiatric disorders, and to thefamilies of those diagnosed with schizophrenia.

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Over the last two decades, molecular genetics and brain imaging have guided efforts to find the causes of schizophrenia. It is becoming increasingly clear that many genes are involved in schizophrenia and that they interact with other factors in very complex ways, which have not yet beenelucidated. Neuroimaging techniques have allowe...

Peter Williamson is at University of Western Ontario.

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Format:HardcoverDimensions:298 pages, 6.18 × 9.29 × 1.1 inPublished:October 12, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195176375

ISBN - 13:9780195176377

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Table of Contents

1. The Evolving Concept of Schizophrenia2. Candidate Neuronal Circuits3. When Does Schizophrenia Begin?4. Clues from Drugs Which Affect Dopamine, Glutamate, and Other Neurotransmitters5. Clues from Psychophysiology6. Neuropsychological Studies7. Imaging Brain Structure in Living Patients8. Imaging Brain Function in Living Patients9. Imaging Brain Chemistry and the Question of Neuronal Degeneration10. Likely Components of the Final Common Pathway11. Early Models of the Final Common Pathway 1. Disconnection and Coordination12. Early Models of the Final Common Pathway 2. Basal Ganglia-Thalamocortical Circuits13. Do the Models Fit With What We Know About Schizophrenia?14. Implications for Treatment15. The Way Forward

Editorial Reviews

"This is a dense, logical, knowledgeable synthesis of the available data from neurotransmitter, psychophysiological, and brain imaging studies which bear on the etiology of schizophrenia."--Journal of Nervous and Mental Disease