Mitochondria and Cancer by Keshav SinghMitochondria and Cancer by Keshav Singh

Mitochondria and Cancer

byKeshav SinghEditorLeslie Costello

Paperback | October 29, 2010

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alfunctiontoprovidethebioenergetic/synthetic/growthrequirementsforthep- gression of the neoplastic cell to malignancy. In the absence of the metabolic transformation,theneoplasticmalignantcellwillnotachieveitsmalignantpot- tial. Thus,itiscriticaltoestablishtheroleofthemitochondriainthemalignant process. Moreover,speci?calterationsindifferentcancertypesmustbeidenti?ed. Such information will provide new approaches to the treatment and perhaps preventionofdifferingcancers. TheadventofMetabolomicsforthedetectionof v vi Preface cancer and progression of malignancy is dependent upon the elucidation and identi?cationofalteredmetabolismandmitochondrialfunction. Thus,thisexciting journeyincancerresearchhasbarelybegunandhasalongwaytogo. Thisbook, Mitochondria and Cancer, and its subject matter provide a roadmap and the preparationtoproceedonthisjourney. Wearegreatlyindebtedtothecontributingauthorsfortheirenthusiasticsupport andwritingachapterintheirareaofexpertise. WearegratefultoMs. DonnaOvak for secretarial help and our families for their patience and support in putting togetherthisbook. Thisbookisdedicatedtopast,present,andfuture"mitoch- driacs"aroundtheworld. Buffalo,NY KeshavK. Singh Baltimore,MD LeslieC. Costello Contents MitochondriaandCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 KjerstinM. Owens,J. S. Modica-Napolitano,andKeshavK. Singh WarburgandhisLegacy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 MichaelRistowandTimJ. Schulz TheLipogenicSwitchinCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 KoenBrusselmansandJohannesV. Swinnen CitrateMetabolisminProstateandOtherCancers . . . . . . . . . . . . . . . . . . . . . . . . . 61 RentyB. FranklinandLeslieC. Costello IntegrationofGenetic,Proteomic,andMetabolicApproachesin TumorCellMetabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 LeslieC. CostelloandRentyB. Franklin MitochondrialRespirationandDifferentiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 RobertoScatena,PatriziaBottoni,andBrunoGiardina IntegrationofEnergyMetabolismandControlofApoptosis inTumorCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 JohnG. PastorinoandJanB. Hoek EnergyGeneratingPathwaysandtheTumorSuppressorp53 . . . . . . . . . . . 131 ChadA. Corcoran,YingHuang,andM. SaeedSheikh MitochondrialTumorSuppressors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 BoraE. Baysal MitochondriainHematology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 StefanieZanssen vii viii Contents MitochondriaandOncocytomas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 J. Lima,V. Ma´ximo,P. Soares,R. Portugal,S. GuimaraËes, andM. Sobrinho-SimoËes MitochondriaasTargetsforCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 StephenJ. RalphandJiriNeuzil ReversingtheWarburgEffect:MetabolicModulationasa NovelCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251 GopinathSutendraandEvangelosD. Michelakis MitochondrialNanotechnologyforCancerTherapy . . . . . . . . . . . . . . . . . . . . . . 265 VolkmarWeissig,GerardG. M. D'Souza,Shing-MingCheng, andSarathiBoddapati Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281 Contributors BoraE. Baysal DepartmentofPathology,YaleUniversitySchoolofMedicine,310CedarStreet, NewHaven,CT06520-8023,USA,bora. baysal@yale. edu SarathiBoddapati Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA PatriziaBottoni DipartimentodiMedicinadiLaboratorio,Universita` CattolicadelSacroCuore, LargoA. Gemelli8,00168Rome,Italy KoenBrusselmans LaboratoryforExperimentalMedicineandEndocrinology,KatholiekeUniversiteit Leuven,Leuven,Belgium Shing-MingCheng Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA ChadA.
Title:Mitochondria and CancerFormat:PaperbackDimensions:289 pagesPublished:October 29, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1441927387

ISBN - 13:9781441927385

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Table of Contents

Mitochondria and Cancer.- Warburg and his Legacy.- The Lipogenic Switch in Cancer.- Citrate Metabolism in Prostate and Other Cancers.- Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism.- Mitochondrial Respiration and Differentiation.- Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells.- Energy Generating Pathways and the Tumor Suppressor p53.- Mitochondrial Tumor Suppressors.- Mitochondria in Hematology.- Mitochondria and Oncocytomas.- Mitochondria as Targets for Cancer Therapy.- Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy.- Mitochondrial Nanotechnology for Cancer Therapy.