Mitochondrial Dysfunction in Ageing and Diseases by Jaime M. RossMitochondrial Dysfunction in Ageing and Diseases by Jaime M. Ross

Mitochondrial Dysfunction in Ageing and Diseases

Guest editorJaime M. Ross, Giuseppe Coppotelli, Lars Olson

Hardcover | August 16, 2016

Pricing and Purchase Info


Earn 816 plum® points

Prices and offers may vary in store


In stock online

Ships free on orders over $25

Not available in stores


The past decade has witnessed an explosion of knowledge regarding how mitochondrial dysfunction may translate into ageing and disease phenotypes, as well as how it is modulated by genetic and lifestyle factors. Impairment of the mitochondria may be caused by mutations or deletions in nuclear or mitochondrial DNA. Hallmarks of mitochondrial dysfunction include decreased ATP production, decreased mitochondrial membrane potential, swollen mitochondria, damaged cristae, increased oxidative stress, and decreased mitochondrial DNA copy number. In addition to energy production, mitochondria play an important role in regulating apoptosis, buffering calcium release, retrograde signaling to the nuclear genome, producing reactive oxygen species (ROS), participating in steroid synthesis, signaling to the immune system, as well as controlling the cell cycle and cell growth. Dysfunctional mitochondria have been implicated in ageing and in several diseases, many of which are age-related, including mitochondrial diseases, cancers, metabolic diseases and diabetes, inflammatory conditions, neuropathy, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Additionally, a possible link between mitochondrial metabolism and the ubiquitin-proteasome and autophagy-lysosome systems is emerging as a novel factor contributing to the progression of several human diseases.
This special issue calls for original research, mini and full reviews, and perspectives that address the progress and current standing in the vast field of mitochondrial biology. These include, but are not limited to:
neurodegenerative diseases
mitochondrial diseases
metabolic diseases
protein homeostasis
cell/retrograde signaling
oxidative stress
immune system
therapies to counteract mitochondrial dysfunction

Title:Mitochondrial Dysfunction in Ageing and DiseasesFormat:HardcoverProduct dimensions:542 pages, 9.61 × 6.69 × 1.63 inShipping dimensions:9.61 × 6.69 × 1.63 inPublished:August 16, 2016Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038422517

ISBN - 13:9783038422518


Table of Contents

(1) Preface to "Mitochondrial Dysfunction in Ageing and Diseases"(2) Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA Instability(3) Mitochondria Retrograde Signaling and the UPRmt: Where Are We in Mammals?(4) Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA(5) Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?(6) Skeletal Muscle Mitochondrial Energetic Efficiency and Aging(7) Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link(8) Autophagy as a Regulatory Component of Erythropoiesis(9) Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction(10) Thyroid Hormone Mediated Modulation of Energy Expenditure(11) Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach(12) Mitochondria as Key Targets of Cardioprotection in Cardiac Ischemic Disease: Role of Thyroid Hormone Triiodothyronine(13) Mitochondrial Mechanisms in Septic Cardiomyopathy(14) Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury(15) Mitochondria: A Therapeutic Target for Parkinson's Disease?(16) The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis(17) Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials(18) Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria- Targeted Anticancer Agents(19) Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors(20) Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy(21) Mitochondria-Derived Reactive Oxygen Species Play an Important Role in Doxorubicin-Induced Platelet Apoptosis(22) Abnormal Mitochondrial Function and Impaired Granulosa Cell Differentiation in Androgen Receptor Knockout Mice