Mitochondrial Dysfunction In Neurodegenerative Disorders by Amy K. Reeve

Mitochondrial Dysfunction In Neurodegenerative Disorders

byAmy K. ReeveEditorEve M. Simcox, Michael R. Duchen

Hardcover | June 21, 2016

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This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson''s disease, Alzheimer''s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. 

Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. 

Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Amy K. Reeve Amy did her undergraduate degree in Neuroscience at Edinburgh University before moving to the Mitochondrial Research Group at Newcastle University for her PhD studies. She completed her PhD in the study of the molecular mechanisms of neurodegenerative disease in 2007 and now has her own research group within the Wellcome T...
Title:Mitochondrial Dysfunction In Neurodegenerative DisordersFormat:HardcoverProduct dimensions:380 pages, 9.25 X 6.1 X 0 inShipping dimensions:380 pages, 9.25 X 6.1 X 0 inPublished:June 21, 2016Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319286358

ISBN - 13:9783319286358

Appropriate for ages: All ages

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Table of Contents

Part I. Mitochondria and Neurodegenerative Disease.- An Introduction to Mitochondria, Their Structure and Functions.-Part II. Mitochondrial Dysfunction: Causes and Effects?.- Neurodegeneration in Mitochondrial Disorders.- The Ageing Brain, Mitochondria and Neurodegeneration.- Mitochondrial Genes and Neurodegenerative Disease.- Mitochondrial Signalling and Neurodegeneration.-Par t III. Functional Consequences of Mitochondrial Dysfunction.- Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson''s Disease.- Mitochondrial Dynamics and Neurodegeneration.- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation.- Mitochondria, the Synapse, and Neurodegeneration.- Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration.- Mitochondrial Degradation, Autophagy and Neurodegenerative Disease.- The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria.-Part IV. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease.- Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?.- Mitochondrial Function and Dynamics ImagedIn Vivo.-Part V.  The Future.- Development of Treatments and Therapies to Target Mitochondrial Dysfunction.- Summary and Conclusions.